EGF can significantly reduce healing time of skin lesions in patients with pemphigus vulgaris, at least when this cream base is applied (Cochrane skin group identifier: CSG20).

Background & Aims:The bipolar disorder is important mental disorder, which is characterized by recurrent episodes of mania and depression. This chronic and complex disease affects the mood of the patient, causing continuous and abnormal mood changes from extremely good to extremely poor and depressed. These fluctuations often last for weeks or months. Frequent episodes of depression and mania affect the functioning of the individual in personal, professional, family, social, and cultural domains. Patients with the bipolar disorder experience a phenomenon known as stigma. Stigma is defined as a set of cognitions and behaviors that are activated by labeling, leading to social exclusion and isolation. The stigma of mental illness distinguishes the patients from other populations. The stigma of mental illness renders the patients incapacitated and socially isolated. In addition, the experience of stigma decreases the quality of life and health-seeking behaviors of the patients, threatening their socio-economic health. Subsequently, the social participation of patients with mental illness is disrupted, and they refrain from seeking social assistance. In fact, stigma leads to the rejection of patients with mental illness by the society, disrupting their emotional regulation and making them unable to have proper emotional regulation strategies. Furthermore, the stigma of mental illness causes the patients not to have appropriate coping strategies for the disease, hide their medical history from the medical staff, and avoid communicating with their friends after discharge from the hospital. Given the importance of the concept of stigma, identifying the positively correlated behaviors seems essential. Self-compassion is a positive behavior that may be associated with stigma. Individuals with high self-compassion are more likely to accept negative life events and have more accurate self-assessments and better mental health. Self-compassion is an important factor in the adaptive responses to the mood problems in patients with a history of recurrent depression. High self-compassion reduces the mental vulnerability of patients with mental illness to problems, their depression and social anxiety, shame caused by the illness, and selfcriticism. In contrast, the lack of self-compassion leads to self-judgment, a sense of further isolation, and a rush of negative emotions about oneself, which ultimately lead to the loss of intimacy in the relationships with others. Low self-compassion is present in a wide range of individuals with mental disorders and causes emotional distress, so that individuals with mental illness and low self-compassion are more likely to have suicidal thoughts. The present study aimed to assess the correlation between stigma and self-compassion in patients with the bipolar disorder. Materials & Methods: This cross-sectional, descriptive-analytical study was conducted on 200 patients with the bipolar disorder admitted to Iran Psychiatric Center in Tehran, Iran, who were selected via continuous sampling. Data w...

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Introduction:The relationship between skin, neuron system and mental status is complicated. Pemphigus is severe and painful autoimmune skin disorder that occurs in 0.5–1 person in 100000 (Mooler & Stanley, 1990).Objective & Aim:Regarding the critical role of mental status in autoimmune diseases such as pemphigus, the aim of this research is to study of psychiatric comorbidity in patient with Pemphigus.Materials & Methods:The society of this research included the patients with Pemphigus inferred to Razi Hospital of skin diseases in Tehran. Participants were 200 persons who were selected through available sampling. Finally 198 persons filled out the demographic questionnaire and SCL-90.Results:This research showed that the prevalence of psychiatric disorders in this sample was 62.62%. 28.78% of patients were male and 33.84% were female. In both genders the symptoms of paranoia were the most prevalent disorders (45% in female and 60% in male) and phobia was the least prevalent in our sample. The upper grade in education, the less prevalent disorders. 81.45% of participants with mental disorders were married and 18.55% of them were single. Of patients only 26.32% had visited the psychiatrist or psychologist and 95.15% of them had used medications.Conclusions:The results showed that psychiatric disorders in patients with Pemphigus is high compared to general population. Thus dermatologists must recognize and manage these comorbidities to treat patients effectively and to improve the quality of life in patients with autoimmune diseases such as Pemphigus.