BACKGROUND The techniqueoflaparoscopiccholecystectomy still has areas requiring refinement, including complications of clips being dislodged. The use of the ultrasonically activated scalpelfor tissuecuttingand coagulation is apotential replacementfor electrosurgery, which can be related to differentc omplications. Theh armonic scalpel was previously used forthe divisionofthe cystic artery andliver-beddissection.Recent advancesinharmonicscalpel technology nowprovide safe division and closure of the cystic ductupto6mm in diameter. 1-5 TECHNIQUE This wasap rospective study of 22 patients undergoing laparoscopic cholecystectomy using the harmonic scalpel. The harmonic scalpelw as used as thes ole instrument for division of thec ysticduct and artery as well as dissection of the liverbed. Theaverage age of thep atientsw as 42.5 years (range, 22-61 years) with 5males and 17 females. Theaverage operation time was 34 min. Thea verage postoperative in-patient stay was 7.2h(all discharged on thesame day of surgery).Nopatientsdeveloped postoperative haemorrhage or bile leakage.