Purpose: Myelin water imaging (MWI) provides a valuable biomarker for myelin, but clinical application has been restricted by long acquisition times. Accelerating the standard multi-echo T 2 acquisition with gradient echoes (GRASE) or by 2D multislice data collection results in image blurring, contrast changes, and other issues.Compressed sensing (CS) can vastly accelerate conventional MRI. In this work, we assessed the use of CS for in vivo human MWI, using a 3D multi spin-echo sequence. Methods: We implemented multi-echo T 2 relaxation imaging with compressed sensing (METRICS) and METRICS with partial Fourier acceleration (METRICS-PF).Scan-rescan data were acquired from 12 healthy controls for assessment of repeatability. MWI data were acquired for METRICS in 9 m:58 s and for METRICS-PF in 7 m:25 s, both with 1.5 × 2 × 3 mm 3 voxels, 56 echoes, 7 ms ΔTE, and 240 × 240 × 170 mm 3 FOV. METRICS was compared with a novel multi-echo spinecho gold-standard (MSE-GS) MWI acquisition, acquired for a single additional subject in 2 h:2 m:40 s. Results: METRICS/METRICS-PF myelin water fraction had mean: repeatability coefficient 1.5/1.1, coefficient of variation 6.2/4.5%, and intra-class correlation coefficient 0.79/0.84. Repeatability metrics comparing METRICS with METRICS-PF were similar, and both sequences agreed with reference values from literature. METRICS images and quantitative maps showed excellent qualitative agreement with those of MSE-GS. | 1265 DVORAK et Al.
The standard myelin water imaging (MWI) sequence for cervical spinal cord, 3D gradient and spin echo (GRASE), was modified to allow scanning in “normal mode” (limiting imaging parameters that may cause physiologic stress) for patients who may not tolerate peripheral nerve stimulation or tissue heating due to MR-conditional implants or medical issues. Traditional 32-echo GRASE was replaced with 48-echo GRASE in normal mode. Myelin water fraction maps from the new sequence had better repeatability than the standard sequence. 48-echo GRASE is the recommended sequence for MWI in spinal cord, particularly for subjects who cannot be scanned outside of normal mode.
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