A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

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Enhanced activity and selectivity towards either α3β2 or α2β4 nicotinic acetylcholine receptors compared to parent compound.

A One-Pot Synthesis of 3-Nitrothiophene and 3-Nitro-2-substituted Thiophenes. -(MCNABOLA, N.; O'CONNOR, C. J.; ROYDHOUSE, M. D.; WALL, M. D.; SOUTHERN*, J. M.; Tetrahedron 71 (2015) 28, 4598-4603, http://dx.doi.org/10.1016/j.tet.2015.05.032 ; Trinity Biomed. Sci. Inst., Trinity Coll., Dublin 2, Ire.; Eng.) -M. Tismer 42-138