Johne's Disease or paratuberculosis is a mycobacterial infection of ruminants and has a global economical impact. Mycobacterium avium subsp. paratuberculosis is the cause of this disease. It reduces milk production, cause chronic weight loss leading death and major losses. Acute phase reactions are defined as minimum 25% increase or decrease in serum concentrations of acute phase proteins which are triggered by pro or antiinflammatory cytokines released from various cells or tissues. The aim of the study was to investigate the effect of Mycobacterium avium subsp paratuberculosis on blood parameters, some acute phase proteins, cytokines and hepcidin in naturally infected goats with paratuberculosis. In this study, total 45 Saanen goats aged 2-5 years from both sex were used as animal material. Study group were included 35 and control group were included 10 animal for evaluation. Complete blood counts were performed on blood taken from all animals. Also interleukin 6, interleukin 10, serum amyloid A, haptoglobin, fibrinogen, and hepcidin levels were evaluated from serum samples. As a result, interleukin 6 (p<0.01), interleukin 10 (p<0.01) serum amyloid A (p<0.001), haptoglobin (p<0.001), fibrinogen (p<0.05), and hepcidin (p<0.05) differences between groups were statistically important and they can be used to support the diagnosis of paratuberculosis.

She presented fever, lethargy, icteric mucous membrans, abdominal bloating and anorexia. An Ehrlichia canis infection was confirmed by blood smear and indirect immunofluorescence assay (IFAT) method. At the examination of blood smear marked anemia and anisocytosis were observed in erythrocytes. Ehrlichia spp. morulae stage were observed in cytoplasm of neutrophils. Blood samples were taken from cat for haematological and biochemical analysis. The cat was treated with doxycycline and recovered rapidly.

Summary:A clinical, hematological and pathological study was carried out on a bovine case of diabetes mellitus (DM) presenting clinical sings of polydipsia, polyuria, glycosuria, hyperglycemia, progressive emaciation and decreased milk yield. The body temperature, heart and respiratory rates were in normal range. Also there was no significant change in hematological values. Prior to slaughter; blood and urine samples were taken twice 48 hour interval from the cow. At necropsy, liver was pale and enlarged. Multiple small white foci were observed on the cortical area of the kidneys. Lung edema and foamy exudates in the lumen of the trachea and bronchus was present. At the gross examination pancreas was in normal appearance. Histopathologically reduced number and size were observed at the pancreatic islet localized in all pancreatic lobes. Decreased cell number observed in the Langerhans islets. Vacuolization and degenerations at the beta cells were commonly seen. Immunohistochemical study of pancreatic tissue revealed a marked reduction in the concentration and distribution of insulin, proinsulin, and amylin, but an increase in glucagon secreted cells. According to the clinical, histopathological and immunohistochemical findings, a combination of diabetes mellitus and multiorgan damage were diagnosed in a cow.

Objective. In this study, it was aimed to compare the effectiveness of Hydroxyethyl Starch (HTS), HTS +7.2% NaCl combination and Ringer Lactate solutions in the treatment of hypovolemic calves with diarrhea. Materials and methods. A total of 21 holstein calves (12 female, 9 male, weighted 28-52 kg), at the age of 0-30 days, were enrolled in the present study. The calves were randomly divided into 3 groups. Calves in the first group received HTS (10 mL / kg), calves in the second group received Hydroxyethyl starch + 7.2% NaCl combination (4 mL/kg) and calves in the third group were treated with lactated Ringer's solution (32 mL/kg) intravenously. Calves in each group were administered with oral rehydration solution immediately, and at 8 th and 16 th hours after intravenous applications. Clinical examinations and laboratory findings were obtained at 0 hour, 30 th minutes, 1 st , 2 nd , 4 th , 12 th and 24 th hours respectively. Results. Calves in all groups achieved clinical remission with a positive response to treatment and there was no statistically significant difference in the vast majority of the variables examined, although dehydration, capillary refill time, mental status and pulse quality were better in hydroxyethyl starch group and especially in hydroxyethyl starch + 7.2% NaCl group than those of Ringer's lactate group (p<0.05). Conclusions. In the present study, treatment of hypovolemic calves with diarrhea especially with Hydroxyethyl starch and Hydroxyethyl starch + 7.2% NaCl combination along with oral fluid therapy with the electrolyte solution was considered to be practical and effective.Key words: Calf diarrhea, hypovolemia, hydroxyethyl starch, hydroxyethyl starch + 7.2% NaCl (Source:CAB). RESUMENObjetivo. En este estudio, que tuvo como objetivo comparar la eficacia de hidroxietil almidón (HEM), HEM + 7.2% en combinación con NaCl y soluciones lactato de Ringer en el tratamiento de los terneros hipovolémicos con diarrea. Materiales y métodos. Un total de 21 terneros Holstein (12 hembras, 9 machos, con pesos entre 28-52 kg) y edad de 0-30 días, fueron consideradas en el presente estudio. Los terneros fueron divididos aleatoriamente en 3 grupos. Terneros en el primer grupo recibieron HEM (10 ml/kg), los terneros en el segundo grupo recibieron almidón + combinación hidroxietil 7.2% de NaCl (4 ml/kg) y terneros en el tercer grupo fueron tratados con solución lactato de Ringer (32 ml/kg) por vía intravenosa. A los terneros en cada grupo se les administró Rev.MVZ Córdoba 21(2):5316-5327, 2016. ISSN: 0122-0268 ORIGINAL 5317 solución de rehidratación oral inmediatamente después, y las ocho y a las 16 horas después de las aplicaciones intravenosas. Los exámenes clínicos y de laboratorio se obtuvieron a las 0 h, 30 minutos, 1, 2, 4, 12 y 24 de horas respectivamente. Resultados. Los terneros en todos los grupos alcanzaron la remisión clínica con una respuesta positiva al tratamiento y no hubo diferencia estadísticamente significativa en la mayoría de las variables examinadas; a pesar de la deshidrata...