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In European and many African, Middle Eastern and Southern Asian populations lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the last 10,000 years 1 . While LP selection and prehistoric milk consumption must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions 2,3 . We provide detailed distributions of milk exploitation across Europe over the last 9k years using c. 7,000 pottery fat residues from >550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Surprisingly, comparison of model likelihoods indicates that LP selection varying with levels of prehistoric milk exploitation provides no better explanation of LP allele frequency trajectories than uniform selection since the Neolithic. In the UK Biobank 4,5 cohort of ~500K contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests other hypotheses on the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available, but that under particular conditions and microbiological milieux this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitationproxies for these driversprovide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.

No abstract

New research in southeastern Anatolia at Early Neolithic sites has brought a fresh perspective on the emergence of the Neolithic way of life in southwest Asia. In addition to providing more details on the transition to settled life, food production, and technological innovations, this more recent work has increased our understanding of both the time span and geography of the last hunter-gatherers and the earliest farmers in the wider region. Now the picture of the beginning of the Neolithic is more complex and fragmented. This complexity necessitates a multifaceted approach to the questions of the emergence of the Neolithic. In this regard, the data coming from Pre-Pottery Neolithic A sites in southeastern Anatolia, particularly in the Upper Tigris Basin, is remarkable. In this paper the transitional stage to the Neolithic in the region and new data from Gusir Höyük is discussed according to the architectural data.