Release of antigen E-'*' I Tmm the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing l.Ck1.2 mg ofAl/rnl was administered rather than an aqueous preparation. The rates of '*'I excretion were similarly influenced being statistically slower through the first week after single doses of the alum-precipitated preparations. The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines.

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