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It is estimated that about 3.4 billion people in 92 countries are at risk of being infected with malaria and developing disease and 1.1 billion are at high risk. The number of malaria cases in south Karnataka in 2019 accounted over 3000 which declined from 2018. It is observed that the occurrence of malaria cases increases during the begining of monsoon mostly in June, thus showing the reoccurrence of malaria disease. The aims of the study were to: 1) To determine the level of knowledge of adults regarding prevention of malaria 2) To find association between the knowledge scores and the selected demographic variables. In order to achieve the objectives of the study, a quantitative research design with descriptive approach was adopted. Data was collected using structured questionnaire and Convenience sampling technique was used to select the 50 samples from selected community, Mangalore.The findings of the present study revealed that majority (60 %) of the respondents had good knowledge, 40% had average knowledge, no one had poor knowledge on prevention of malaria. The present study showed mean knowledge score 20.12 and standard deviation ±2.264. The study revealed that adults have some knowledge regarding prevention of malaria. There was no association between the knowledge score and demographic variables. The study concluded that educating the adults in community is the best way to prevent malaria outbreak in the community.