In the present study a various phytochemical compounds that have been isolated from Melia azedarach and showed phytoconstituents from leaves against three of pathogenic fungi are as follows: Alternaria alternate, Neoscytalidium dimidiatum and Sordaria fimicola. ''The Phytochemical of M. azedarach leaves were exposed to (GC-MS) analysis. The results showed highest activity against reviewed fungal, (Alternaria alternate, Neoscytalidium dimidiatum and Sordaria fimicola). All three concentrations of extract (20,30,40 mg/ml) in respectively"  were given a results ( 0.00 )mm in the diameter of colonies. The GC-MS analysis of Melia azedarach leaves parts showed the presence of؛ Ethyl methyl phthalate ؛ diethyl benzene-1,2-dicarboxylate ؛ Methyl hexadecanoate Palmitic acid (hexadecanoic acid)    ؛ 11-octadecenoic acid methyl ester    ؛2-Hexadecen-1-ol,3,7,11,15-tetramethyl-,(2E,7R,11R)- ؛-9-(Z)-Octadecenoic acid ؛1,16-Hexadecanedicarboxylic acid ؛9(Z),12(E)-Octadecadienoic acid ؛9,19-cyclolanost-24-en-3-ol  ؛3-beta-5-alpha-6-beta-trihydroxycholestan  ؛4-Stigmasten-3-one  ؛9,19-Cyclo-9.beta.-lanost-25-en-3.beta.-ol, 24-methyl-, (24S)-  ؛(R,R,R)-alpha-Tocopherol   ؛4-(4-ethylcyclohexyl)-1-pentyl-cyclohexene ) ؛4,4-Dimethyl-5-.alpha.-cholestan-3-.beta.-ol   ؛  5alpha-Stigmastan-3,6-dione ؛(22E)-Stigmast-22-en-3-one ؛Cholest-8-en-3.beta.-ol ؛(2-Dodecen-1-yl)succinic anhydride, technical.