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Context: Ethnomedicinally, the roots of Thalictrum foliolosum DC has long been used traditionally in opthalmia as a collyrium, improves eye-vision, relieves toothache, in diarrhea, cure piles to god extent, nail troubles, and also in discoloration of the skin. Because of lack of proper identification of plants, standardization of crude drugs becomes difficult. So, to ensure efficacy, safety and purity of T. foliolosum, there is a requirement to create quality control parameters by using pharmacognostical and phytochemical screening. Aim: To perform evaluation of pharmacognostical parametrs including organoleptic, microscopical and physico-chemical and phytochemical screening of T. foliolosum roots. Methods: organoleptic and microscopical characters of dried sample of root were observed. Physico-chemical parameters performed by applying WHO guidelines, fluorescence analysis and phytochemical screening of root sample were also completed for standardization and identification of root of T. foliolosum. Results: Macroscopical characters like color, odor, shape, texture, size, fracture were observed from root and powdered root material of T. foilolosum. Microscopical characters of root showed the presence of parenchymatous cells, cork cells along with pitted and sclariform vessels.Phytochemical evaluation specified the presence of various secondary plant metabolites like alkaloids, steroids, saponins, proteins, tannins, flavonoids and triterpenoids. Physico-chemical parameters such as extractive value, Moisture content, ash value, florescence behavior of root powder was performed. These all evaluated parameters help to distinguish the powdered drug material. Conclusion: This current study will help in standardization and identification along with carrying out further research in herbal medicinal system.

Background: Cancer is one of the leading causes of death worldwide, and the pain associated with it is very intense. Plants are a significant source of medications, particularly anticancer and analgesic medicines. One significant plant, Strobilanthes Kunthiana, is well-known for its assortment of medical applications. As a result, additional studies were carried out using these two Phytocosntituents, lupeol and betulin, to examine their analgesic and anticancer characteristics using PDB IDs 2MUB and 4XI3. The examination on the basis of molecular docking and ADME profiles served as the foundation for this study. Objective: Based on molecular docking investigations, to suggest a mechanism of Strobilanthes Kunthiana Phytocosntituents for anticancer and analgesic activity. Method: Molecular docking studies of Phytoconstituents of Strobilanthes Kunthiana were performed using the PyRx Virtual Screening software. Results:According to the results of molecular docking, numerous ingredients, such as lupeol and betulin exhibit higher dock scores better than standard medications against analgesic and anticancer targets. Conclusion: Based on molecular docking studies. Various chemical constituents may act as effective inhibitors of various proteins 2MUB, 4XI3. This information can be used to design new anticancer medicines.

Development of drugs against diabetes has always remained a big challenge among the medicinal chemists around the globe because of its continuously increasing prevalence worldwide. The emergence of benzothiazole as a prominent lead against diabetes is credited to the development of the aldose reductase inhibitor, Zopolrestat. Since then, there has been a continuous effort to develop benzothiazole derivatives as potential antidiabetic probes, especially in the last two decades. Use of computer aided drug designing tools such as molecular docking and pharmacophore modelling have also played a crucial role in the exploration of efficacy of benzothiazole against other targets for diabetes. In this review, possible targets for benzothiazole against diabetes will be discussed with the brief role each target plays in maintaining the normal blood glucose level in the body. A trend analysis of the emergence of different inhibitors over various intervals of time along with the structure-activity relationship (SAR) studies of benzothiazole as antidiabetic probe is incorporated in the end of the study.

Background: Plants remains a source of food as wells as medicine and healthcare needs since the dawn of civilization. Plants and plants derived products are available in crude form as well as in dosage forms which are widely prescribed by the medical practitioners and believed safe to consume as compared to the synthetic compounds based medicines. Many bioactive compounds derived from the plant sources are utilized in various health problems. A vast research on the medicinal plants has been conducted worldwide but there are many plants species which are still unexplored. Despite having ethnic reports as medicine, a very lesser number of plant species of the genus. Methods: We have been consulting various articles from scientific data available on internet specially, ScienceDirect, Scopus, PubMed, Web of Science. Thalictrum of family Ranunculaceae have been explored scientifically in terms of pharmacology, phytochemistry, bioactivity studies. Results: Thalictrum is the genus of plants bear flowers in the family Ranunculaceae containing about 200 species in the diverse region of the globe.