Malaria is one of the leading life-threatening vectors borne diseases prevalent in tropical and subtropical regions of the world. The traditional system of medicine uses drugs of plant origin. Quinine and artemisinin, two naturally occurring plant chemicals, are traditionally used to treat malaria. The present reviews have emphasized the anti-malarial activity of plants that are effective against emerging resistance. The aim of the present study was to analyze the concept and objectives of isolated natural compounds, their mechanism of action, and plant parts used for malaria treatment in the traditional system of medicine. 113 isolated compounds, plant parts used from 49 species, and molecular mechanism of 70 anti-malarial natural compounds from various plant species were explored. These plants were traditionally used for malaria treatment worldwide. They are therapeutically more effective, safer, and traditionally reported for having high cure rates. There is an urgent need for the development of novel drugs to treat malaria. These isolated compounds may be explored for the development of antimalarial drugs against plasmodium-resistant strains.

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