Magnetic
hyperthermia treatment using calcium phosphate nanoparticles
is an evolutionary choice because of its excellent biocompatibility.
In the present work, Fe3+ is incorporated into HAp nanoparticles
by thermal treatment at various temperatures. Induction heating was
examined within the threshold Hf value of 4.58 ×
106 kA m–1 s–1 (H is
the strength of alternating magnetic field and f is
the operating frequency) and sample concentration of 10 mg/mL. The
temperature-dependent structural modifications are well correlated
with the morphological, surface charge, and magnetic properties. Surface
charge changes from +10 mV to −11 mV upon sintering because
of the diffusion of iron in the HAp lattice. The saturation magnetization
has been achieved by sintering the nanoparticles at 400 and 600 °C,
which has led to the specific absorption rate of 12.2 and 37.2 W/g,
respectively. Achievement of the hyperthermia temperature (42 °C)
within 4 min is significant when compared with the existing magnetic
calcium phosphate nanoparticles. The systematic investigation reveals
that the HAp nanoparticles partially stabilized with FeOOH and biocompatible
α-Fe2O3 exhibit excellent induction heating.
In vitro tests confirmed the samples are highly hemocompatible. The
importance of the present work lies in HAp nanoparticles exhibiting
induction heating without compromising the factors such as Hf value, low sample concentration, and reduced duration
of applied field.
A 5 at.% Dy3+ ions doped CaWO4 nanoparticles (CaWO4:5Dy) were synthesized by hydrothermal
method using polyethylene glycol (PEG) as solvent medium and capping agent. The phase purity and
crystalline properties of the prepared nanoparticles were obtained from the XRD analysis. TEM images
revealed that the CaWO4:Dy3+ have particles of size approximately in the range 30-50 nm. The prepared
magnetic luminescence nanocomposite exhibits a high saturation magnetization. The prepared
nanocomposite can achieve hyperthermia temperature (42 ºC) in a short period by applying the
alternating magnetic field, externally. The nanocomposite also shows photoluminescence properties.
Nanomaterials described in this work can be used for optical imaging as well as hyperthermia
applications.
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