The authors analyzed the blood of a group of 336 smokers and 336 non-smokers to determine if tobacco smoke, potentially the major source of nitrogen oxide pollution for 40% of the adult population, significantly reduces oxygen carrying capacity as a result of methemoglobin formation. Each blood sample was analyzed for carboxyhemoglobin, methemoglobin, and hemoglobin using an automated spectrophotometer. The mean value of methemoglobin in the smokers did not exceed that in the non-smokers; in fact, the level in the non-smokers was significantly greater. As expected, carboxyhemoglobin levels in smokers substantially exceeded those in non-smokers. The authors conclude that methemoglobin arising from cigarette smoke exposure does not interfere with the oxygen carrying capacity of the blood in smokers.

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