Introduction: Glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) approved to date are administered by injection; therefore, patient perceptions of an oral GLP-1 RA are unknown. This discrete choice experiment explored preferences for (unbranded) oral and injectable GLP-1 RA profiles among Japanese patients with type 2 diabetes (T2D). Methods: An online survey was designed using literature review and qualitative interview findings, and administered to Japanese patients with T2D

Modern society is increasingly dependent on reliable performance of distributed systems. In this paper, we provide a precise definition of performance using the concept of quality attenuation; discuss its properties, measurement and decomposition; identify sources of such attenuation; outline methods of managing performance hazards automatically using the capabilities of the Recursive InterNetworking Architecture (RINA); demonstrate procedures for aggregating both application demands and network performance to achieve scalability; discuss dealing with bursty and time-critical traffic; propose metrics to assess the effectiveness of a performance management system; and outline an architecture for performance management.

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This paper directly addresses a long-standing issue that affects the development of many complex distributed software systems: how to establish quickly, cheaply, and reliably whether they can deliver their intended performance before expending significant time, effort, and money on detailed design and implementation. We describe ΔQSD, a novel metrics-based and quality-centric paradigm that uses formalised outcome diagrams to explore the performance consequences of design decisions, as a performance blueprint of the system. The distinctive feature of outcome diagrams is that they capture the essential observational properties of the system, independent of the details of system structure and behaviour. The ΔQSD paradigm derives bounds on performance expressed as probability distributions encompassing all possible executions of the system. The ΔQSD paradigm is both effective and generic: it allows values from various sources to be combined in a rigorous way so that approximate results can be obtained quickly and subsequently refined. ΔQSD has been successfully used by a small team in Predictable Network Solutions for consultancy on large-scale applications in a number of industries, including telecommunications, avionics, and space and defence, resulting in cumulative savings worth billions of US dollars. The paper outlines the ΔQSD paradigm, describes its formal underpinnings, and illustrates its use via a topical real-world example taken from the blockchain/cryptocurrency domain. ΔQSD has supported the development of an industry-leading proof-of-stake blockchain implementation that reliably and consistently delivers blocks of up to 80 kB every 20 s on average across a globally distributed network of collaborating block-producing nodes operating on the public internet.

Agile software development and Formal Methods are traditionally seen as being in conflict. From an Agile perspective, there is pressure to deliver quickly, building vertical prototypes and doing many iterations/sprints, refining the requirements; from a Formal Methods perspective, there is pressure to deliver correctly and any change in requirements often necessitates changes in the formal specification and might even impact all arguments of correctness. Over the years, the need to "be agile" has become a kind of mantra in software development management, and there is a prevalent prejudice that using formal methods was an impediment to being agile. In this paper, we contribute to the refutation of this stereotype, by providing a real-world example of using good practices from formal methods and agile software engineering to deliver software that is simultaneously reliable, effective, testable, and that can also be iterated and delivered rapidly. We thus present how a lightweight software engineering methodology, drawing from appropriate formal methods techniques and providing the benefits of agile software development, can look like. Our methodology is informed and motivated by practical experience. We have devised and adapted it in the light of experience in delivering a large-scale software system that needs to meet complex real-world requirements: the Cardano blockchain and its cryptocurrency ada. The cryptocurrency domain is a rather new application area for which no clear engineering habit exists, so it is fitting well for agile methods.