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Use of clinical indicators succeeded in supporting clinicians to monitor practice standards and to realize change in systems of care and clinician behaviour.

Ventilator-associated pneumonia (VAP) is the most common healthcare-associated infection in the intensive care unit. Clinical, radiological and microbiological criteria are used to make the diagnosis, but there is no consensus definition, as no individual criterion or combination of criteria offer sufficient diagnostic accuracy to support their sole use in defining VAP. Neither invasive bronchoscopic sampling nor less invasive quantitative tracheal aspirate, conveys an advantage when making the microbiological diagnosis of VAP. Of the scoring systems and definitions presently in use, the Clinical Pulmonary Infection Score (CPIS) has been shown to be prone to inter-observer variability; the US Centers for Disease Control (CDC) National Healthcare Safety Network (NHSN) definition relies heavily on subjective clinical criteria, and the Hospitals in Europe Link for Infection Control through Surveillance (HELICS) criteria employ similarly subjective clinical criteria with five different possibilities for microbiological diagnosis. The use of these different diagnostic methods leads to marked variation in the reported incidence of VAP. Clinical practice requires an objective and transferable definition for VAP so that we can improve the reporting, monitoring and treatment of VAP.

Potentially harmful effects of positive pressure mechanical ventilation have been recognized since its inception in the 1950s. Since then, the risk factors for and mechanisms of ventilator-induced lung injury (VILI) have been further characterized. Publication of the ARDSnet tidal volume trial in 2000 demonstrated that a ventilator strategy limiting tidal volumes and plateau pressure in patients with acute respiratory distress syndrome was associated with a 22% reduction in mortality. Since then, a variety of ventilator modes have emerged seeking to improve gas exchange, reduce injurious effects of ventilation, and improve weaning from the ventilator. We review here emerging ventilator modes in the intensive care unit (ICU). Airway pressure release ventilation seeks to optimize alveolar recruitment and maintain spontaneous ventilatory effort. It is associated with improved indices of respiratory and cardiovascular physiology, but data to support outcome benefit are lacking. High-frequency oscillatory ventilation is associated with improvements in gas exchange, but outcome data are conflicting. Extracorporeal modes of ventilation continue to evolve, and extra-corporeal CO(2) removal is a technique that could be used in non-specialist ICUs. Proportional-assist ventilation and neutrally adjusted ventilator assist are modes that vary level of assistance with patient ventilatory effort. They result in greater patient-ventilator synchrony, but at present there is no evidence of a reduction in the duration of mechanical ventilation or outcome benefit. Although the use of many of these modes is likely to increase in intensive care units, further evidence of a beneficial effect is desirable before they are recommended.

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