Although reef coral skeletal carbon isotopes (δ 13 C) are routinely measured, interpretation remains controversial. Here we show results of a consistent inverse relationship between coral δ 13 C and skeletal extension rate over the last several centuries in Porites corals at Fiji, Tonga, Rarotonga and American Samoa in the southwest Pacific. Beginning in the 1950s, this relationship breaks down as the atmospheric 13 C Suess effect shifts skeletal δ 13 C > 1.0‰ lower. We also compiled coral δ 13 C from a global array of sites and find that mean coral δ 13 C decreases by −1.4‰ for every 5 m increase in water depth ( R = 0.68, p < 0.01). This highlights the fundamental sensitivity of coral δ 13 C to endosymbiotic photosynthesis. Collectively, these results suggest that photosynthetic rate largely determines mean coral δ 13 C while changes in extension rate and metabolic effects over time modulate skeletal δ 13 C around this mean value. The newly quantified coral δ 13 C-water depth relationship may be an effective tool for improving the precision of paleo-sea level reconstruction using corals.

Background: Chronic kidney disease (CKD) is common in patients with type 2 diabetes mellitus (T2DM) and limits therapeutic options. Dipeptidyl peptidase-4 (DPP-4) inhibitors represent a novel class of oral glucose-lowering agents and are known to be safe and effective in the general population. Methods: We searched Cochrane, EMBASE, and PubMed from the time of their inception until March 2015. We included randomized controlled trials analyzing the efficacy (change in hemoglobin A1C [HbA1C]) and safety of DPP-4 agents in individuals with reduced kidney function (estimated glomerular filtration rate <60 mL/min/1.73 m²). We extracted study characteristics, participants' baseline characteristics, and safety outcomes from eligible studies. We performed a random effects meta-analysis to summarize the change in HbA1C and the relative risk of cardiovascular events in patients with T2DM and CKD. We also collected data on hypoglycemia, other serious adverse events, and mortality. Results: We reviewed 12 studies with 4,403 patients with CKD and 239 on dialysis, finding a mean weighted decline in HbA1C of -0.48 (95% CI -0.61 to -0.35) with DPP-4 inhibitor therapy compared to placebo. DPP-4 inhibitors did not result in any additional adverse events, hypoglycemic episodes, or increased mortality. Restricting to studies with low risk of bias did not alter these findings. Conclusions: DPP-4 inhibitors can lower HbA1C without increasing the risk of cardiovascular or other major adverse events in patients with CKD. Few studies reported critical adverse events such as heart failure and hypersensitivity. If compared with other oral antiglycemic drugs, the effect of DPP-4 inhibitors is limited; however, their low risk of hypoglycemia may favor their use in patients with CKD. Summary: This systematic review of DPP-4 inhibitors in CKD suggests that they reduce HbA1C by about 0.5%. Furthermore, there was not any increase in the risk for significant adverse events. More research is needed to determine the safety and efficacy of DPP-4 inhibitors in CKD.

A 492‐year‐long, continuous δ18O time series from a massive Porites coral colony in Ta'u, American Samoa, records contrasting responses to different types of El Niño‐Southern Oscillation (ENSO) through a mixed sea surface temperature and salinity signal. Currently, conventional El Niño (La Niña) events generate cold and salty (warm and fresh) anomalies at Ta'u, while Modoki El Niño (La Niña) events warm (cool) the waters at Ta'u. Over the course of the twentieth century, the Ta'u δ18O record underwent a polarity shift in its response to conventional ENSO: A warm and fresh (cool and salty) response to El Niño (La Niña) was replaced by the opposite pattern. We interpret this as evidence for the movement of the Eastern Pacific ENSO null zone, the narrow band of the surface ocean where sea surface temperature variability is not on average correlated with ENSO. This movement appears to be related to overall shrinking of the ENSO footprint over the twentieth century. We infer no such trend in the Modoki footprint. The five‐century‐long Ta'u record shows dramatic, century‐scale changes in ENSO‐band variability. Comparisons with other ENSO reconstructions lead to conflicting interpretations: The Ta'u coral may have recorded changes in the strength of ENSO or in its spatial footprint. Changes in the spatial footprint manifest as a changing sensitivity to ENSO at any given location, presenting challenges to established methods of ENSO reconstruction.

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Despite global efforts to monitor, mitigate against, and prevent trash (mismanaged solid waste) pollution, no harmonized trash typology system has been widely adopted worldwide. This impedes the merging of datasets and comparative analyses. We addressed this problem by 1) assessing the state of trash typology and comparability, 2) developing a standardized and harmonized framework of relational tables and tools, and 3) informing practitioners about challenges and potential solutions. We analyzed 68 trash survey lists to assess similarities and differences in classification. We created comprehensive harmonized hierarchical tables and alias tables for item and material classes. On average, the 68 survey lists had 20.8% of item classes in common and 29.9% of material classes in common. Multiple correspondence analysis showed that the 68 surveys were not significantly different regarding organization type, ecosystem focus, or substrate focus. We built the Trash Taxonomy Tool (TTT) web-based application with query features and open access at openanalysis.org/trashtaxonomy. The TTT can be applied to improve, create, and compare trash surveys, and provides practitioners with tools to integrate datasets and maximize comparability. The use of TTT will ultimately facilitate improvements in assessing trends across space and time, identifying targets for mitigation, evaluating the effectiveness of prevention measures, informing policymaking, and holding producers responsible.