Highlights d A scRNA-seq study reveals shared and distinct features of human MMRd and MMRp CRC d Co-variation of single-cell transcriptional programs across specimens predicts immune hubs d A myeloid-rich inflammatory hub is identified below the colonic lumen in human CRC d CXCR3-ligand+ cells form foci with activated T cells in human MMRd CRC

This cohort study uses data from the National Cancer Database to assess the association between receipt of treatment at minority-serving vs non–minority-serving hospitals and use of palliative care among racial/ethnic minorities with cancer.

The benefits of breastfeeding for both women and infants are well established. 1 Despite recommendations from the American Academy of Pediatrics and the World Health Organization, initiating and sustaining lactation remains a challenge for many women. 2 Although 79% of mothers in the United States initiate breastfeeding, only 27% are still breastfeeding at 12 months postpartum. 3 Physicians who are mothers face substantial challenges that may undermine efforts to sustain lactation after they return to work. Elsewhere, we demonstrated that the career satisfaction of physicians who are mothers was negatively affected by the short duration of maternity leave, associated financial losses, and inflexible work schedules. 4-6 Given the paucity of data on lacta-tion practices among physicians who are mothers, the aim of this study was to use a large representative nationwide cohort to evaluate the barriers to breastfeeding for physicians who are mothers.