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We studied ultrastructure of cardiomyocytes of W/SSM rats with inherited hypertrophic cardiomyopathy bred from Wistar rats by hypersensitivity to cataractogenic action of high galactose doses. The observed dynamics of quantitative and qualitative changes in the main sarcoplasmic organelles reflects general principles of spatial and temporal reorganization of cardiac muscle cells induced by hypertrophy of different genesis.Key Words: W/SSM rats; hypertrophic cardiomyopathy; cardiomyocytes; electron microscopy; morphometry; stereology W/SSM rats with inherited hypertrophic cardiomyopathy were bred from Wistar rats selected by hypersensitivity to cataractogenic action of high galactose doses at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science [8,12,13]. These animals are characterized by spontaneous myocardium hypertrophy accompanied by diffuse stroma collagenization, focal sclerotic changes, and chronic cardiac insufficiency [6,7,9].One of the mechanisms of pathologic process is based on changes in plasma membrane integrity resulting from enhanced hexose transport into the cells, generation of free hydroxyradicals, and intensification of lipid peroxidation [ 1,17]. In the myocardium of W/ SSM rats with genetically determined disturbances of the carbohydrate metabolism and increased lysosome Thus, hypertrophic changes in the myocardium of W/SSM rats are similar to those observed during idiopathic human hypertrophic cardiomyopathy in the absence of anatomic or physiologic causes [11].The aim of the present study was to reveal intracellular changes in CMC and to determine ultrastructural stereological parameters typical of W/SSM rats with genetically determined hypertrophic cardiomyopathy. MATERIALS AND METHODSForty male W/SSM rats aged 3 and 10 months and 20 -male Wistar rats of the same age kept under standard vivarium conditions were used in the experiment. The animals were weighed and decapitated under chloro-

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