Lipossomas são vesículas constituídas de uma ou mais bicamadas INTRODUÇÃOAlec Bangham há 40 anos com sua observação pioneira de que fosfolipídeos em soluções aquosas podem formar estruturas fechadas em bicamadas, permitiu que a pesquisa sobre os lipossomas percorresse um longo caminho, convertendo-os de simples objetos de pesquisa biofísica em carreadores terapêuticos para numerosas aplicações clínicas (Torchilin, 2005).Os primeiros resultados das pesquisas foram, entre-

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The aim of this study was to determine the antibacterial and antibiofilm properties of quercetin against clinical isolates of Staphyloccocus aureus and Staphylococcus saprophyticus with resistance profile. The antibacterial activity of quercetin was performed by the determination of the minimum inhibitory concentration (MIC) through the microdilution method according to the Clinical and Laboratory Standards Institute (CLSI). The percentage of inhibition of Staphylococcus spp. biofilm, after treatment with sub-inhibitory concentrations of quercetin (MIC/2 and MIC/4), was evaluated by the violet crystal assay. Quercetin showed an antimicrobial activity against clinical isolates of methicillin-susceptible S.