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Rothmund-Thomson syndrome (RTS) is a rare genodermatosis with characteristic skin changes such as atrophy, abnormal pigmentation and telengiectasias, skeletal abnormalities, short stature, juvenile cataract and predisposition to skin and bone malignancies. Data from the literature suggest that cutaneous findings of the syndrome include genetically programmed ageing changes and DNA repair abnormalities related to photosensitivity. Our patient is a 23-year-old male who presented with an unhealing ulcer for one and a half year on his left leg. Although he had received many various treatments, there had been no significant improvement during this period. We believe that this failure of healing might be to DNA repair abnormalities of fibroblasts. To our knowledge, this is the first case reported with coexistence of an unhealing ulcer without any findings of malignancy and RTS.

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ÖzetAmaç: Psoriasis vulgaris, hastalar›n yaflam kalitesini önemli ölçüde etkileyen kronik bir hastal›kt›r. Hastal›¤a özgü gelifltirilen ilk ölçek olan "Psoriasis ‹fllev Kayb› ‹ndeksi" (P‹K‹), pek çok dilde geçerlilik ve güvenilirli¤ini kan›tlam›fl ve klinik çal›flmalarda kullan›lm›flt›r. Bu çal›flmada amac›m›z, P‹K‹'ni Türkçeye çevirerek, dilimizde geçerlili¤ini ve güvenilirli¤ini araflt›rmakt›. Gereç ve Yöntem: Ölçek, uluslararas› çeviri basamaklar› izlenerek Türkçeye çevrildi. Hastalar›n Psoriasis alan fliddet indeksi (PAfi‹) skorlar›, demografik ve klinik bulgular› kaydedildi. Güvenilirlik analizi için "iç yap› tutarl›l›¤›" ve "test-tekrar test" metotlar› kullan›ld›. Ölçekteki her bir soru ve alt gruplar için Cronbach alfa katsay›s› ve madde-toplam puan korelasyonlar› hesapland›. Geçerlilik analizi için, "Dermatoloji Yaflam Kalite ölçe¤i"(DYKÖ) ile karfl›laflt›rma yöntemi kullan›ld›. Elde edilen P‹K‹ skorlar›, hastalar›n demografik bulgular› ve klinik özellikleri ile karfl›laflt›r›ld›. Bulgular: Çal›flmaya 161 psoriasis hastas› al›nd›. ‹çyap› tutarl›l›k ölçümünde tüm alt ölçeklerin Cronbach alfa katsay›s› 0,61-0,79 aras›nda de¤iflmekte olup, tüm anket için 0,88 olarak hesapland›. Test-tekrar test güvenilirli¤inde, her bir soru için korelasyon katsay›s› 0,366-0,775 aras›nda de¤iflmekte olup, toplam P‹K‹ skoru için korelasyon katsay›s› r=0,854 olarak hesapland› (p<0,001). Geçerlilik analizleri için, ortalama P‹K‹ ve DYKÖ skorlar› aras›ndaki iliflki araflt›r›ld› ve her iki ölçek aras›nda korelasyon katsay›s› r= 0,674 bulundu (p<0,05). Sonuç: Çal›flmam›z, yap›lan güvenilirlik ve geçerlilik ölçümleri sonucunda P‹K‹'nin Türk psoriasis hastalar› için uygun bir ölçek oldu¤unu göstermektedir. (Türkderm 2011; 45: 24-8) Anahtar Kelimeler: Dermatoloji yaflam kalite ölçe¤i, psoriasis, psoriasis ifllev kayb› indeksi, yaflam kalitesi, türkçe versiyon Summary Background and Design: Several instruments are available for assessing impairment and disability associated with psoriasis. The first psoriasis-specific quality of life questionnaire, Psoriasis Disability Index (PDI), has been translated to many different languages and used in studies all around the world. The aim of this study was to translate the PDI into Turkish and to validate the Turkish version of the PDI and its use for Turkish psoriasis patients, as well as to examine the specific contribution of demographic and clinical features to the PDI. Material and Method: The questionnaire was translated into Turkish by using appropriate translation steps. The socio-demographic data and the Psoriasis Area and Severity Index (PASI) scores of the patients were recorded. For reliability analysis, internal consistency and test-retest method were used. The Cronbach's alpha coefficient and item-total statistics were calculated for each question and subscales. For validation, the questionnaire was compared with the Dermatology Life Quality Index (DLQI). Results: A total of 161 psoriasis patients were included in the study. For internal consistency, Cronbach's alpha coefficient...

The fact that hypothyroidism, hyperthyroidism, and antithyroid drugs cause alopecia appears in classic medical books. No studies assess the presence, the frequency, and the types of alopecia that can be seen in thyroid patients. We evaluate the presence, frequency, and the types of alopecia seen in 286 female patients with thyroid disease and 141 healthy women. Alopecia was investigated by clinical examination, hair pull test, dermoscopy and, if necessary, by biopsy. Compared with the control group, female pattern hair loss (FPHL) and diffuse hair loss (DHL) was statistically higher in the study group. The incidence of alopecia areata (AA) was not different, even in the patients with autoimmune thyroid diseases. The duration of thyroid disease was significantly longer in patients with FPHL. A significant difference in the types of alopecia in patients with thyroid disease was not found. We found that the DHL is infrequent in thyroid patients, alopecia is a rare presenting sign, antithyroid medicine usage does not appear to cause alopecia, and alopecia areata (AA) is not now common in patients with thyroid disease. Finally, FPHL is frequently found in patients with thyroid disease and is related to the duration of the disease. Learning Objectives• Define the different types of alopecia associated with thyroid disease.• Describe the useful diagnostic tests for alopecia. • Outline the association between specific types of alopecia and specific types of thyroid disease.T he fact that hypothyroidism, hyperthyroidism, and the drugs used to treat these diseases are thought to cause alopecia is a common concept. 1 Diffuse loss of scalp hair occurs in 20% to 40% of thyrotoxic patients. Scalp hair is fine and soft, and holds a permanent wave poorly in these patients. The hair is dull, coarse, and brittle in hypothyroidism. Up to 50% of hypothyroid patients are noted to experience diffuse hair loss (DHL). 2 For these reasons, thyroid function tests are recommended for patients with DHL. 1,3 Antithyroid medications can also cause hair loss, probably by inducing a hypothyroid state. Methylthiouracil, propylthiouracil, and carbimazole are all reported to produce this effect. 4 These concepts are old, however, and supporting data are often subjective and difficult to interpret. In this report, we evaluate the presence, the frequency, and the types of alopecia in patients with thyroid disease. MATERIALS AND METHODSA cross-sectional study was performed in 286 female patients (mean age: 44, 52 Ϯ 13, 80) with thyroid disease and 141 healthy females (mean age: 44, 23 Ϯ 14, 19). The diagnosis of thyroid disease was made by hormone levels (free T3, free T4, total T3, total T4, TSH), autoantibodies (antithyroglobulin, antithyroid peroxidase), thyroid ultrasonography, and, in some cases, biopsy. Alopecia was investigated by clinical examination, hair pull test, dermoscopy, and, if necessary, by biopsy. Female pattern hair loss (FPHL) was diagnosed by age of onset, the pattern of increased hair thinning over the frontal/parietal scalp wi...