This study addresses the problem of Alzheimer’s disease (AD) diagnosis with Electroencephalography (EEG). The use of EEG as a tool for AD diagnosis has been widely studied by comparing EEG signals of AD patients only to those of healthy subjects. By contrast, we perform automated EEG diagnosis in a differential diagnosis context using a new database, acquired in clinical conditions, which contains EEG data of 169 patients: subjective cognitive impairment (SCI) patients, mild cognitive impairment (MCI) patients, possible Alzheimer’s disease (AD) patients, and patients with other pathologies. We show that two EEG features, namely epoch-based entropy (a measure of signal complexity) and bump modeling (a measure of synchrony) are sufficient for efficient discrimination between these groups. We studied the performance of our methodology for the automatic discrimination of possible AD patients from SCI patients and from patients with MCI or other pathologies. A classification accuracy of 91.6% (specificity = 100%, sensitivity = 87.8%) was obtained when discriminating SCI patients from possible AD patients and 81.8% to 88.8% accuracy was obtained for the 3-class classification of SCI, possible AD and other patients.
Abstract. This paper describes the objectives, the tasks proposed to the participants and the associated protocols in terms of database and assessment tools of two present competitions on fingerprints and on-line signatures, the results of which will be ready for presentation at the next ICB conference. The particularity of the fingerprint competition is to be an on-line competition, for evaluation of fingerprint verification tools such as minutiae extractors and matchers as well as complete systems. The on-line signature competition will test the influence of multi-session, environmental conditions (still and mobility) and signature complexity on the performance of complete systems using two datasets extracted from the BioSecure database.
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