Background: There is a need for rapid and accurate diagnostic biomarker for diagnosis of Salmonella fever. Aims: The aim of the present study was to assess the utility of procalcitonin (PCT), Soluble Triggering Receptors 1 on Myeloid Cells (sTREM1) and C- reactive protein (CRP) in diagnosis of enteric fever with positive blood culture for S.typhi. Materials and Methods: Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected for determination of CRP, PCT and sTREM-1. Results: The sensitivity and specificity for PCT cut off was 97.7% &82.5% for each, for CRP the sensitivity and specificity were 95.3% and 77% for each and for s-TREM-1 the sensitivity and specificity were 95.3% & 77%. Conclusion: S-TREM-1 may be considered as a novel biomarker for such diagnosis of enteric fever with good sensitivity and specificity.

No abstract

No abstract

No abstract

Background: Carbapenem resistant Klebsiella species [CRK] is increasing worldwide that may necessitate the use of combination therapy of antibiotics. Objectives: our aim was to characterize the main mechanisms of resistance carried by CRK isolates and to investigate the in-vitro efficacy of antibiotic combinations. Methodology: One hundred Klebsiella isolates were used for detection of KPC by modified Hodge test and boronic acid combination disc. PCR was done for detection of KPC, genes. The efficacy of antimicrobials combination against these isolates was also tested. Results: By boronic acid combination disc 62% were positive, by modified Hodge test 12% were positive. By PCR; 18% of isolates were positive for OMP-35, 16% for KPC, 14% OXA-48 and 6% for OMP36 genes. Antibiotic combination results showed that 64 and 26 isolates were sensitive to gentamicin-ciprofloxacin, meropenemciprofloxacin combinations respectively. Conclusion: We concluded that OXA-48, KPC, OMP-35 and OMP-36 genes were circulating in our hospital. Gentamycin and ciprofloxacin Combination may be effective. METHODOLOGY Bacterial isolates:This study was conducted on clinical isolates of 100 CRK isolated from samples sent from Neonatal ICU to the