Ticagrelor did not improve endothelial function or increased systemic adenosine plasma levels as compared with prasugrel and clopidogrel in stabilized patients who suffered from an ACS. (Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans [HI-TECH]; NCT02587260).

Results show and confirm the multidisciplinary interest of the research on look-alike/sound-alike drugs, and the difficulty to perform systematic review or metaanalysis for many clinical questions that have great relevance. This review has identified technology and management solutions that could effectively limit, or eliminate, look-alike/sound-alike drugs errors in hospital wards, or outside the hospital where the risk is more uncontrollable: however look-alike/sound-alike drugs therapy errors are not supported by reliable statistics but events reported in the literature can not be underestimated.

Women showed a higher risk of severe bleeding and access site complications, and radial access was an effective method to reduce these complications as well as composite ischemic and ischemic or bleeding endpoints.

In patients with ACS, the rates of MACEs and NACEs were not significantly lower with bivalirudin than with UFH, irrespective of planned GPI use. However, bivalirudin significantly reduced bleeding complications, mainly those not related to access site, irrespective of planned use of GPIs. (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX [MATRIX]; NCT01433627).

Background Hospital pharmacists can play an important role in reporting adverse drug reaction (ADRs). Several publications underscore the fact that adverse drug events account for a substantial percentage of all hospital admissions. In the literature, several ways are mentioned in which the pharmacist can contribute to the safe use of drugs. Purpose To establish ADRs in the Emergency Room (ER). Materials and Methods This study was conducted from April 2010 to December 2011 in Salerno University Hospital. ADR report forms completed in the first 20 months of the project were analysed. Some of their key principles were collected: sex; suspected drug that caused the reaction and other drugs taken in association; description of ADRs and their classification as non-severe, severe or life-threatening. They were compared with ADR data for 2009. Results 158 forms were analysed, each related to one different patient: 98 patients were women (68%). 50% of the events were connected with antibiotics, e.g. amoxicillin/clavulanic acid (28 cases), penicillin (19 cases), cephalosporins (17 cases); 35% concerned anti-inflammatories such as nimesulide (21%), propionic acid derivatives (21%), acetylsalicylic acid (14%), ketorolac (11%), steroidal anti-inflammatories (7%). 103 patients didn’t take other drugs, but 55 had taken another one. Skin reactions were 52% of events, while 14% were cardiovascular events, 13% gastrointestinal problems, and 8% were respiratory reactions. Non-severe ADRs were 75%; 25% were severe and 1 case life-threatening. Before the project, in 2009 only one ADR had been reported; zero reports in the period January–March 2010. Conclusions It is evident that the presence of a hospital pharmacist in ER increases the number of ADR reports: data confirms that a pharmacist who supports medical staff in reporting ADRs should be operative in all hospital departments. No conflict of interest.