These findings suggest a significant but modest relation between reduced volume in specific temporal lobe regions and neuropsychological deficits in abstraction, categorization, and verbal memory, all of which may reflect a dysfunctional semantic system in schizophrenia.
Posters (Saturday) S145 differences in hippocampal subfield volumes. All tests were corrected for age, sex, body mass index, and total intracranial volume, and test within the FEP group were also corrected for antipsychotic medication. After excluding subjects with diabetes, we tested associations between fasting glucose (<6.2 mmol/l), insulin, HOMA-index, clinical symptoms, and the subfield volumes. Results:We found that several hippocampal subfields (ROI) were significantly smaller in FEP than in controls (ROI × Group P = .010, Partial η 2 .039). In FEP patients particularly molecular layer (P = .001, left β = −38.95, right β = −27.81), subiculum (P = .028, left β = −19.71, right β = −13.35), CA1 (P = .016, left β = −29.73, right β = −28.58) and presubiculum (P = .004, left β = −14.01, right β = −13.92) were smaller than in the controls. Blood fasting glucose-dependent group interaction was found between FEP and control group (Group × Glucose P = .038). Glucose correlated positively with hippocampal volumes in the controls but not in the FEP. In FEP group, fasting glucose levels correlated negatively with volumes in right subiculum (P = .033, β = −25.13), left presubiculum (P = .004, β = −29.31) and right presubiculum (P = .038, β = −21.04). Cognitive tests or symptom severity were not associated with the hippocampal subfield volumes. Conclusion: We showed that hippocampal subregions are differently affected already in the first episode of psychosis. We found that several hippocampal subfields were differently associated with blood glucose levels in FEP and control group. The findings do not provide evidence for causal relationships but suggest that hippocampal subregions are differently involved in the regulation of glucose metabolism in FEP and control group. The results suggest FEP patients are susceptible to the negative effects of impaired glucose metabolism. SA89. ALTERED BRAIN GYRIFICATION IN DEFICIT AND NONDEFICIT SCHIZOPHRENIAYoichiro Takayanagi*, Daiki Sasabayashi, Tsutomu Takahashi, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Mihoko Nakamura, and Michio Suzuki University of Toyama Background: Clinical heterogeneity in patients with schizophrenia has repeatedly been reported. Patients with the deficit form schizophrenia (D-SZ) are characterized by severe primary negative symptoms and differ from patients with the nondeficit form of schizophrenia (ND-SZ) in several aspects including treatment response and clinical outcome. Although several studies have examined gray matter volume, cortical thickness, or cortical connectivity in deficit and nondeficit schizophrenia, there is no study that has measured brain gyrification, which is a potential maker of neurodevelopment, in D-SZ and ND-SZ. Methods: We obtained 1.5-T 3D magnetic resonance scans from 136 patients with schizophrenia and 50 age-and gender-matched healthy controls. Patients in the top quartile on the proxy scale for the deficit syndrome (PDS) were treated as having D-SZ, whereas those in the bottom quartile on PDS were defined as having ND...
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