SYNOPSISCopolymerizations of N-glycinylmaleimide (GMI) with methacrylic acid (MA) and vinyl acetate (VAc) were carried out in 2-butanone using lauroylperoxide as an initiator at 70°C. Synthesized GMI, poly(GM1-co-MA), and poly(GM1-co-VAc) were characterized by IR and 'H-NMR spectroscopies, elemental analysis, and gel permeation chromatography. The in uitro cytotoxicities of poly(GM1-co-MA) and poly(GM1-co-VAc) were evaluated using K-562 human leukemia cells and HeLa cells. From the cytotoxicity data against HeLa cells, the copolymers are less cytotoxic than monomeric GMI at dosage of 0.02, 1.0, and 5.0 mg/ mL. Copolymers were very effective at any dosage tested. The in uiuo antitumor activities of poly(GM1-co-MA) and poly(GM1-co-VAc) were also evaluated against mice hearing sarcoma 180. Monomeric GMI and its copolymers showed higher antitumor activity than 5fluorouracil (5-FU) at any dosage tested. 0

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The new monomer, α‐methoxy‐3,6‐endo‐methylene‐1,2,3,6‐tetrahydrophthaloyl‐5‐fluorouracil (MMTFU), was synthesized from 5‐fluorouracil (5‐FU) and α‐methoxy‐3,6‐endo‐methylene‐1,2,3,6‐tetrahydrophthaloyl chloride (MMTC). Poly(α‐methoxy‐3,6‐endo‐methylene‐1,2,3,6‐tetrahydrophthaloyl‐5‐fluorouracil) [poly(MMTFU)], poly(α‐methoxy‐3,6‐endo‐methylene‐1,2,3,6‐tetrahydrophthaloyl‐5‐fluorouracil‐co‐acrylicco‐AA), and poly(α‐methoxy‐3,6‐endo‐methylene‐1,2,3,6‐tetrahydrophthaloyl‐5‐fluorouracil‐co‐vinyl acetate) [poly(MMTFU‐co‐VAc)] were synthesized by photopolymerizations using 2,2‐dimethoxy‐2‐phenylacetophenone (DMP) as the photoinitiator. The synthesized MMTFU and the polymers were identified by FT‐IR, 1H‐NMR, and 13C‐NMR spectroscopies. The contents of MMTFU in poly(MMTFU‐co‐AA) and poly(MMTFU‐co‐VAc) determined by elemental analysis were 63 and 57 mol %, respectively. The number average molecular weights and polydispersity indices of synthesized polymers determined with GPC were in range of 7,700–19,100 and 1.6–2.7. The in vitro cytotoxicities of samples were evaluated with mouse mammary carcinoma (FM3A), mouse leukemia (P388), and human histiocytic lymphoma (U937) as cancer cell lines and mouse liver cells (AC2F) as a normal cell line. The cytotoxicities of 5‐FU and synthesized samples against cancer cell lines increased in following orders: 5‐FU > MMTFU > poly(MMTFU) > poly(MMTFU‐co‐AA) > poly(MMTFU‐co‐VAc). The in vivo antitumor activities of the synthesized samples against mice bearing the sarcoma 180 tumor cell line were evaluated. The in vivo antitumor activities of the polymers were greater than that of 5‐FU at a dose of 80 mg/kg. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 1625–1632, 1998

SYNOPSISGraft copolymerization of acrylonitrile (AN) and 4-chlorostyrene (4-Clst) onto ethylenepropylene-diene terpolymer ( EPDM ) was carried out using benzoyl peroxide as initiator.The effects of EPDM content, initiator concentration, solvent, mole ratio of 4-Clst to AN, reaction time, and reaction temperature on the graft copolymerization were examined. It was found that the light resistance, weatherability, and thermal stability of the acrylonitrile-EPDM-4-chlorostyrene graft copolymer were considerably better than those of acrylonitrilebutadiene-styrene copolymer. ma1 stability, and tensile properties of the graft copolymer were analyzed. EXPERIMENTAL MaterialsAcrylonitrile (Junsei Chemical) was purified by standard procedures. Benzoyl peroxide ( Hayashi Chemical) was recrystallized from methanol. Ethylene-propylene-diene terpolymer ( EPDM ) , having ethylidene norbornene as a termonomer ( Aldrich Chemical; ethylene/propylene = 50/50 by mol %, ML 50), was used as received. 4-Chlorostyrene (4-Clst) monomer was prepared by dehydration of 4-chlorophenylmethyl carbinol, as described previously." n-Hexane, dimetyl formamide (DMF) , acetone, toluene, cyclohexane, ethyl acetate, and tetrahydrofuran (THF) were distilled prior to use.