O estresse oxidativo decorre de um desequilíbrio entre a geração de compostos oxidantes e a atuação dos sistemas de defesa antioxidante. A geração de radicais livres e/ou espécies reativas não radicais é resultante do metabolismo de oxigênio. A mitocôndria, por meio da cadeia transportadora de elétrons, é a principal fonte geradora. O sistema de defesa antioxidante tem a função de inibir e/ou reduzir os danos causados pela ação deletéria dos radicais livres e/ou espécies reativas não radicais. Esse sistema, usualmente, é dividido em enzimático (superóxido dismutase, catalase e glutationa peroxidase) e não-enzimático. No último caso, é constituído por grande variedade de substâncias antioxidantes, que podem ter origem endógena ou dietética. Objetivou-se revisar os principais mecanismos de geração de radicais livres, bem como a ação dos agentes mais relevantes do sistema de defesa antioxidante, ressaltando suas implicações sobre os marcadores do estresse oxidativo. Também serão abordados os principais fatores exógenos moduladores do estresse oxidativo. Termos de indexação:Antioxidantes. Espécies reativas de nitrogênio. Espécies reativas de oxigênio. Estresse oxidativo. Radicais livres.
Ao se fazer a recomendação de proteína para diferentes grupos populacionais [13], além da composição aminoacídica (SARWAR et al., 1997) [28], devem ser consideradas a quantidade total de nitrogênio e a digestibilidade da mistura protéica. Uma mistura protéica de QUALIDADE NUTRICIONAL E ESCORE QUÍMICO DE AMINOÁCIDOS DE DIFERENTES FONTES PROTÉICAS SUMMARYNUTRITIONAL QUALITY AND CHEMICAL SCORE OF AMINO ACIDS FROM DIFFERENT PROTEIN SOURCES. Proteins are essential for animals, therefore, they must be present in diet, in appropriate amounts. Besides the quantitative aspect, the qualitative aspect should be taken into account, i.e. its nutritional value, which will depend on its composition, digestibility, bioavailability of essential amino acids, absence of toxicity, and of antinutritional factors. The purpose of this work was to evaluate the digestibility in vivo, the chemical score of amino acids (EQ), and the protein digestibility corrected amino acid score (PDCAAS) of the following protein resources: frog meat without bone, frog meat with bone, mechanically separated frog meat (CMS), beef meat, egg powder, casein, wheat, corn, conventional soybean, Kunitz trypsin inhibitor and lipoxygenase free soybean (KTI-LOX-soybean), textured soybean protein (PTS) and beans. Animal proteins presented higher digestibility values than those from vegetables. Frog meat without bone was the protein with the highest protein digestibility of all proteins studied, not differing from casein, CMS, beef and frog meat with bone. Comparing animal proteins, the one of egg powder was the one which presented the lowest digestibility. No animal protein presented essential limiting amino acids when compared to those of FAO/WHO. Beans, conventional soybean, KTI-LOX-soybean and PTS presented sulfurized amino acids (methione+cysteine) as limiting ones. Whereas for wheat and corn, the most limiting amino acid was lysine. KTI-LOX-soybean presented higher PDCAAS values than those of conventional soybean, presenting a possible increase in genetically improved soybean and processed soybean protein quality. Keywords: protein quality, digestibility, PDCAAS, essential amino acids. A digestibilidade é a medida da porcentagem das proteínas que são hidrolisadas pelas enzimas digestivas e absorvidas pelo organismo na forma de aminoácidos ou de qualquer outro composto nitrogenado. Trata-se de um determinante da qualidade protéica da dieta. Quando certas ligações peptídicas não são hidrolisadas no processo digestivo, parte da proteína é excretada nas fezes ou transformada em produtos do metabolismo pelos microorganismos do intestino grosso [30].
OBJETIVO: Analisar o consumo alimentar, o ambiente socioeconômico, a freqüência de anemia ferropriva e o estado nutricional de pré-escolares. MÉTODOS: A população estudada constituiu-se de 89 crianças de 24 a 72 meses de idade, assistidas em creches municipais de Viçosa, MG. Foram avaliados: nível de hemoglobina, peso, estatura, presença de parasitose, consumo alimentar dos pré-escolares e o perfil biossocioeconômico de suas famílias. RESULTADOS: O estado nutricional do grupo foi considerado satisfatório, e a prevalência de anemia relativamente baixa (11,2%). Condições adequadas de saneamento, nível razoável de escolaridade dos pais, baixo número de filhos e ausência de parasitas envolvidos com a gênese da anemia podem justificar o perfil observado. Não foi observada associação da anemia ferropriva nem com desnutrição nem com parasitose. CONCLUSÃO: Apesar de alguns fatores biossocioeconômicos apresentarem-se favoráveis ao estado nutricional e à baixa prevalência de anemia, observa-se, entretanto, que a insuficiente renda per capita e a dieta deficiente poderão levar esse grupo de pré-escolares, no futuro, a um pior estado de saúde.
Objective: Evaluate the effect of high-oleic and conventional peanuts within a hypocaloric-diet on energy metabolism and body composition. Methods: This 4-week randomized clinical trial included males with BMI of 29.7 6 2.4 kg m 22 and aged between 18 and 50 years. Participants were assigned to the groups: control (CT, n 5 22) that followed a hypocaloric-diet; conventional peanuts (CVP, n 5 22) or high-oleic peanuts (HOP, n 5 21) that received the hypocaloric-diet including (not adding) 56 g day 21 of peanuts. Glucose, fat oxidation, and body fatness and lean mass were the main outcomes. Results: Body weight and composition did not differ between groups. However, within group total body fat (kg) reduced with CVP and HOP, with a significant decrease in body fat percentage in HOP. While total lean mass (kg) decreased in CT, total lean mass (%) increased in HOP. Truncal lean mass decreased in the CT. At baseline, HOP had greater postprandial fat oxidation than the CVP. After 4-weeks, fasting fat oxidation increased in CVP and HOP. Fat oxidation increased in CT and HOP during the 200 min after meal intake compared to the fasting condition. Conclusion: Regular peanut consumption, especially the high-oleic type, within a hypocaloric-diet increased fat oxidation and reduced body fatness in overweigh and obese men.
Objective: To evaluate the effects of acute and daily consumption of high-oleic peanuts (HOP) on inflammation and glucose homeostasis in overweight/obese men. Methods: In a 4-week randomized clinical trial, males with body mass index of 29.8 6 2.3 kg/m 2 and aged 18-50 years were assigned to the groups: control (CT, n 5 22); conventional peanuts (CVP, n 5 22); or HOP (n 5 21). They followed a hypocaloric-diet with or without 56 g/day of CVP or HOP. Main outcomes were changes in fasting blood biomarkers and postprandial insulin, glucose, tumor necrosis factor-alfa (TNF-a), and interleukin-10 (IL-10) responses after acute peanut intake. Results: At baseline, HOP showed significantly lower postprandial responses of glucose, insulin, and TNF-a than CVP and CT. Changes in fasting blood biomarkers did not differ between groups after the 4-week intervention. However, within groups, total cholesterol decreased in CT, and all groups reduced High-density lipoprotein (HDL-c). Triglycerides were reduced in HOP and CVP. IL-10 increased significantly in all groups while only the CT and CVP showed increased TNF-a after intervention. Conclusion: Acute high-oleic peanut consumption leads to stronger moderation of postprandial glucose, insulin, and TNF-a concentrations than CVP and control meal intake. Whether daily intake of high-oleic peanuts has additional benefits to CVP remains uncertain.
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