ImportanceThe global impact of COVID-19 has led to an increased need to continuously assess disease surveillance tools. The utility of SARS-CoV-2 serologic tools in determining immunity levels across different age groups and locations in helping to quickly assess the burden of COVID-19 with significant health policy implications is unknown.ObjectiveTo determine the prevalence of SARS-CoV-2 antibodies with respect to the age group and sex of participants.Design, Setting, and ParticipantsA cross-sectional survey of 4904 individuals across 12 states with high and low COVID-19 disease burden in Nigeria was carried out between June 29 and August 21, 2021.Main Outcomes and MeasuresEnzyme-linked immunosorbent assay was used for the detection of specific SARS-CoV-2 immunoglobulin G and immunoglobulin M antibodies, such as the nucleocapsid protein-NCP and spike protein S1. Interviewer-administered questionnaires provided information on participants’ history of disease and associated risk factors.ResultsA total of 4904 individuals participated in the study (3033 were female [61.8%]; mean [SD] age, 26.7 [6.51] years). A high seroprevalence of SARS-CoV-2 (78.9%) was obtained. Seropositivity was consistent across the states surveyed, ranging from 69.8% in Lagos to 87.7% in Borno. There was no association between sex and seropositivity (female, 2414 [79.6%]; male, 1456 [77.8%]; P = .61); however, an association was noted between age and seropositivity, with the peak prevalence observed in participants aged 15 to 19 years (616 [83.6%]; P = .001). Similarly, loss of appetite (751 [82.3%]; P = .04) and smell (309 [84.4%]; P = .01) were associated with seropositivity.Conclusions and RelevanceIn this cross-sectional study, a high SARS-CoV-2 seroprevalence was obtained among the study population during the low level of vaccination at the time of the survey. Thus, there is a need for both an efficacy and antibody neutralization test study to ascertain the efficacy of the antibody detected and the potential for herd immunity in Nigeria.

Background: Knowledge Translation Platforms (KTP) attempt to bridge the "know-do gap" between researchers and policymakers. This study summarized the evidence on activities, as well as methods of monitoring and evaluation projects of KTPs in Low- and Middle-Income Countries (LMICs). Methods: The Arksey and O’Malley methodology for scoping reviews was used. The databases accessed include Medline, Global Health, CINAHL, EBSCO and Cochrane library databases. Only Studies that indicated range of activities, tools or methods used in monitoring and evaluating KTP to achieve the implementation of evidence informed policymaking in LMICs were included. The key words used includes Knowledge Translation, Monitoring and Evaluation, Platforms and Low- and Middle-Income countries. Results: Total of 3150 hits were obtained from the searched databases. 750 duplicates were identified and removed resulting to 2398 articles. Using title screening, 2123 articles were excluded resulting in 275 articles for abstract screening. Abstract screening led to exclusion 246 articles, leaving 29 articles for the full-text screening. Full-text screening resulted to exclusion of 25 articles resulting to 4 articles that meet the inclusion criteria. No relevant articles were obtained from the reference list screening and grey literature search. Conclusion: Evidence shows that Case study methodology is the predominate method of evaluating KTPs. The shortest time duration from generation to use of evidence in decision making was noticed to be 1-year. The range of activities used to monitor KTP in bridging the “know do gap” includes stakeholder’s engagement, building capacity, priority setting, meeting with stakeholders, generating policy brief, litmus testing of brief, stakeholders dialogue, evidence brief and dialogue review, disseminating of findings and implementation. The minimum and maximum number of activities performed in each KTP process is 5 and 8 activities respectively.