Based on one of the viewpoints of building the Biology curriculum, which is integrated education and sustainable development education, helps students strengthen and develop the competency to mobilize and apply integrated knowledge, skills in many different fields to effectively solve problems in study and their’ life. Practical problems in teaching Biology are very diverse, associated with daily life and related to other subjects such as environmental protection, health care, response to the Covid-19 epidemic. ..... The article proposes the process of designing and using integrated practice exercises in teaching Biology in high school in order to develop students' competency to solve practical problems