Aim:To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO 3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF 2 /SHMP with 1450 ppm F). Methods and Materials:Twenty-five subjects were randomized to a two-period, two-treatment, double blind crossover sequence using NaF/KNO 3 (Sensodyne ® ProNamel™ dentifrice) and SnF 2 /SHMP (blend-a-med ® * EXPERT GUMS PROTECTION dentifrice). Each treatment was conducted with a standard manual toothbrush (Oral-B ® P35 Indicator). Digital plaque image analysis (DPIA) was used on three consecutive days to evaluate:(a) overnight plaque formation (A.M. pre-brushing); (b) following 40 seconds of brushing with the test product (A.M. post-brushing); and (c) mid-afternoon (P.M.). Images were analysed using an objective computer algorithm to calculate the total area of visible plaque. A four-day washout period was instituted for the crossover phase. Results:All 25 subjects completed the study. The SnF 2 /SHMP positive control dentifrice provided statistically significantly lower levels of plaque area coverage versus the NaF/KNO 3 test dentifrice at each timepoint. For the SnF 2 /SHMP dentifrice, plaque coverage was 23.0% lower (p<0.0001) at A.M. pre-brushing, 17.3% (p=0.0163) lower at A.M. post-brushing, and 22.6% (p= 0.0004) lower at the P.M. measure relative to the NaF/KNO 3 dentifrice. Abstract © Seer PublishingClinical Significance: Dentists recommending an effective home use dentifrice for patients experiencing dentinal hypersensitivity and/or dental erosion may previously have needed to compromise on other key benefits, such as plaque control. blend-a-med ® EXPERT GUMS PROTECTION is a dentifrice when integrated into an oral hygiene routine can provide a proven treatment for hypersensitivity, dental erosion, and a reduction in the regrowth of plaque.