We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated the HBN dMRI data (N = 2747) into the Brain Imaging Data Structure and preprocessed it according to best-practices, including denoising and correcting for motion effects, susceptibility-related distortions, and eddy currents. Preprocessed, analysis-ready data was made openly available. Data quality plays a key role in the analysis of dMRI. To optimize QC and scale it to this large dataset, we trained a neural network through the combination of a small data subset scored by experts and a larger set scored by community scientists. The network performs QC highly concordant with that of experts on a held out set (ROC-AUC = 0.947). A further analysis of the neural network demonstrates that it relies on image features with relevance to QC. Altogether, this work both delivers resources to advance transdiagnostic research in brain connectivity and pediatric mental health, and establishes a novel paradigm for automated QC of large datasets.

Although ostensibly gendered as men and frequently maintaining independent, patriarchal households, enslaved eunuchs (khwājasarās) in pre- and early colonial regimes in South Asia were often mocked for their supposed effeminacy, bodily difference, and pretensions to normative masculinity. In the Mughal successor state of Awadh (1722-1856), such mockery grew more pronounced in the wake of growing financial demands from the British East India Company and attempts by eunuchs to alienate property with wills and testamentary bequests. Through examples of verbal derision directed at eunuchs, this essay shows that not only did ideas of normative masculinity serve as a vehicle for Awadh’s rulers to defend their sovereign authority from colonial encroachment, but that notions of normative manhood continued to inform eunuchs’ own self-perception into the nineteenth century.

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Over the course of the eighteenth century, India's Mughal empire (1526–1858) fragmented into a number of regional polities that were, in turn, gradually subsumed under the paramount authority of the British East India Company. This essay describes concomitant developments in the empire's Persianate political language, particularly with regard to ideas of sovereignty, statehood, and dominion. It argues that by the mid-eighteenth century, the Mughal “empire of Hindustan” was increasingly framed as a territorialised governing institution comprising emerging provincial sovereignties rooted in local ruling households. This conceptual dispensation, however, remained ill-defined until the 1760s, when a treaty regime dominated by the Company built upon this language to concretise the empire as a confederacy of independent, sub-imperial states. The essay contends that in the short term, this redefinition bolstered the authority of incipient dynasties in provinces like Awadh, but in the longer term generated conflicts that abetted the expansion of colonial rule and laid conceptual foundations for British paramountcy in India.