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Low density lipoprotein (LDL) particle size is inversely associated with plasma triglyceride concentration in cross-sectional analyses. In the present study, changes in the LDL particle size of 227 participants of the Framingham Offspring Study were analyzed longitudinally by nondenaturing gradient gel electropho-resis at two examinations that were separated by 3-4 years. All subjects had triglyceride concentrations <400 mg/dl at both exams. Using laser scanning densitometry to assess mean LDL particle size, 56% of samples displayed a change in size: 41% had a one-band size change, 13% had a two-band change, and 2% had a three-band change. These changes in size corresponded to a 15% change in pattern type, based on pattern A and B terminology. There was a significant inverse association between change in LDL size and change in triglyceride (/><0.0001) and glucose (p<0.004) concentrations, body weight (p<0.02), and age (p<0.03). There was also a significant positive association with change in high density lipoprotein (HDL) cholesterol concentration (p<0.0001). Change in LDL cholesterol concentration, as calculated by use of the Friedewald formula, however, showed no significant association with change in LDL size (p<0.9). There was also no significant association with change in smoking or blood pressure, but there was a nonsignificant inverse trend associated with alcohol intake (p<0.08j. Women had more significant changes than men, but the relation between change in LDL size and change in lipids was the same for women and men. In stepwise regression analyses of biochemical indices, change in triglyceride concentration produced the best single-variable model (r=0.460). When change in HDL cholesterol concentration was added to the model, the r value increased slightly to 0.481 for the two-variable model. No other variables entered the model. We conclude that the amount of circulating triglyceride appears to be the single most important factor affecting LDL particle size and that LDL size can be modulated by changes in plasma triglyceride concentration. (Arteriosclerosis and Thrombosis 1992; 12:1284-1290) KEY WORDS • low density lipoproteins • low density lipoprotein subspecies • triglycerides • high density lipoprotein cholesterol • gradient gel electrophoresis S ince low density lipoproteins (LDL) have been implicated in the development of coronary artery disease (CAD), they have been closely studied by a number of research groups. 1-7 LDL have been shown to be a heterogeneous population of particles with respect to size, density, and composition and have been studied through the use of density gradient and analytical ultracentrifugation, as well as with nondenaturing polyacrylamide gradient gel elec

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The media often play the role of translating new science to consumers. We discuss the recent literature that has examined the supply and demand factors that affect media coverage of new food technologies and the impact on public perceptions and consumer behavior toward food that utilizes these technologies. We start with a discussion of the ways in which the media influence public perceptions and consumer behavior related to foods made with new technologies. We then discuss the incentives of news media and the potential sources of biases in their reporting. We review empirical studies that have examined media reporting of new agricultural and food technologies, especially biotechnology, in terms of both their agenda setting and framing effects and the social amplification of risk. We synthesize the findings of studies that have examined the influence of media coverage on public attitudes and consumer behavior. We conclude and discuss avenues for future research. 19.1