Test methods used in the assessment of activity are discussed, utilizing the gradient plate dilution technique of Curry (1) for screening work. The various classes of surfactants studied included anionics, nonionics, amphoterics, and cationics. A study was made in vitro of the influence of these surface‐active agents on five antimicrobial agents. Based upon these tests it appears that, in general, Temasepts I, II, and IV show greater activity and a broader spectrum than G‐11 and TCC. This is particularly evident in the presence of conventional soap and the newer non‐soap bars. An interesting pattern of results was observed when nonionic BC720 was used in the system. All of the antimicrobial agents were equal in activity againstStaphylococcus aureus, Escherichia coli, andCandida albicans, but Temasept I showed the highest activity againstPityrosporum ovale andAspergillus niger, with TCC occupying an intermediate position. The cationic vehicles alone, in addition to any possible enhancement of the ring‐halogenated aromatics, contribute significantly in the system to inhibit all of the test strains. With the amphoteric vehicles, the antimicrobial agents for the most part were equally effective, with G‐11 being slightly less effective. In striking contrast, the three Temasepts showed far greater activity againstP. ovale, C. albicans, andA. niger, especially in Miranol CS. The data presented may be utilized for the formulation of fabric softeners, and the tests employed aid in the selection of the proper surfactant for textile and skin applications. The work demonstrates that in any technical appraisal of the antimicrobial potency of a compound, the influence of the surfactant vehicle is of paramount importance.

The versatility of two brominated salieylanilides as antiseptic agents and germicides in soap and detergent products for use on skin, hair, hard surfaces and in fabrics is discussed.Both preparations show stability at elevated temp and pressure and compatibility with many surfactant vehicles. They are free of primary irritation and sensitization, including sunlightinduced irritation.A mixture of di-and tribromosalicylanilide is currently being used in toilet bars, shampoos, laundry products, disinfectant sprays and multipurpose disinfectant products. The substantivity to fabrics is further characterized by stability to heat and hydrolysis by alkalinity.Essentially pure 3,4',5 tribromosalieylanilide is resistant to discoloration, making it particularly suitable for use in white and pastel colored toilet bars. It has excellent substantivity to skin and provides long-lasting action against odor-causing and pathogenic bacteria.

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