Thermoelectric generators (TEGs) convert temperature differences into electrical power and are attractive among energy harvesting devices due to their autonomous and silent operation. While thermoelectric materials have undergone substantial improvements...
Background Using the spin‐lattice relaxation time (T1) as a biomarker, the myocardium can be quantitatively characterized using cardiac T1 mapping. The modified Look–Locker inversion (MOLLI) recovery sequences have become the standard clinical method for cardiac T1 mapping. However, the MOLLI sequences require an 11‐heartbeat breath‐hold that can be difficult for subjects, particularly during exercise or pharmacologically induced stress. Although shorter cardiac T1 mapping sequences have been proposed, these methods suffer from reduced precision. As such, there is an unmet need for accelerated cardiac T1 mapping. Purpose To accelerate cardiac T1 mapping MOLLI sequences by using neural networks to estimate T1 maps using a reduced number of T1‐weighted images and their corresponding inversion times. Materials and Methods In this retrospective study, 911 pre‐contrast T1 mapping datasets from 202 subjects (128 males, 56 ± 15 years; 74 females, 54 ± 17 years) and 574 T1 mapping post‐contrast datasets from 193 subjects (122 males, 57 ± 15 years; 71 females, 54 ± 17 years) were acquired using the MOLLI‐5(3)3 sequence and the MOLLI‐4(1)3(1)2 sequence, respectively. All acquisition protocols used similar scan parameters: TR=2.2ms$TR\; = \;2.2\;{\rm{ms}}$, TE=1.12ms$TE\; = \;1.12\;{\rm{ms}}$, and FA=35∘$FA\; = \;35^\circ $, gadoteridol (ProHance, Bracco Diagnostics) dose ∼0.075mmol/kg$\sim 0.075\;\;{\rm{mmol/kg}}$. A bidirectional multilayered long short‐term memory (LSTM) network with fully connected output and cyclic model‐based loss was used to estimate T1 maps from the first three T1‐weighted images and their corresponding inversion times for pre‐ and post‐contrast T1 mapping. The performance of the proposed architecture was compared to the three‐parameter T1 recovery model using the same reduction of the number of T1‐weighted images and inversion times. Reference T1 maps were generated from the scanner using the full MOLLI sequences and the three‐parameter T1 recovery model. Correlation and Bland–Altman plots were used to evaluate network performance in which each point represents averaged regions of interest in the myocardium corresponding to the standard American Heart Association 16‐segment model. The precision of the network was examined using consecutively repeated scans. Stress and rest pre‐contrast MOLLI studies as well as various disease test cases, including amyloidosis, hypertrophic cardiomyopathy, and sarcoidosis were also examined. Paired t‐tests were used to determine statistical significance with p<0.05$p < 0.05$. Results Our proposed network demonstrated similar T1 estimations to the standard MOLLI sequences (pre‐contrast: 1260±94ms$1260 \pm 94\;{\rm{ms}}$ vs. 1254±91ms$1254 \pm 91\;{\rm{ms}}$ with p=0.13$p\; = \;0.13$; post‐contrast: 484±92ms$484 \pm 92\;{\rm{ms}}$ vs. 493±91ms$493 \pm 91\;{\rm{ms}}$ with p=0.07$p\; = \;0.07$). The precision of standard MOLLI sequences was well preserved with the proposed network architecture (24±28ms$24 \pm 28\;\;{\rm{ms}}$ vs. 18±13ms$18 \pm 13\;{\rm{ms}}...
Surface acoustic wave (SAW) devices are a subclass of micro-electromechanical systems (MEMS) that generate an acoustic emission when electrically stimulated. These transducers also work as detectors, converting surface strain into readable electrical signals. Physical properties of the generated SAW are material dependent and influenced by external factors like temperature. By monitoring temperature-dependent scattering parameters a SAW device can function as a thermometer to elucidate substrate temperature. Traditional fabrication of SAW sensors requires labor- and cost- intensive subtractive processes that produce large volumes of hazardous waste. This study utilizes an innovative aerosol jet printer to directly write consistent, high-resolution, silver comb electrodes onto a Y-cut LiNbO3 substrate. The printed, two-port, 20 MHz SAW sensor exhibited excellent linearity and repeatability while being verified as a thermometer from 25 to 200 ∘C. Sensitivities of the printed SAW thermometer are $$-96.9\times 1{0{}^{-6}}^{\circ }$$ − 96.9 × 1 0 − 6 ∘ C−1 and $$-92.0\times 1{0{}^{-6}}^{\circ }$$ − 92.0 × 1 0 − 6 ∘ C−1 when operating in pulse-echo mode and pulse-receiver mode, respectively. These results highlight a repeatable path to the additive fabrication of compact high-frequency SAW thermometers.
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