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The United States (U.S.) nuclear industry is facing a strong challenge to maintain regulatory required levels of safety while ensuring economic competitiveness to stay in business. Safety remains a key parameter for all aspects related to the operation of light water reactor (LWR) nuclear power plants (NPPs) and can be achieved more economically by using a risk-informed ecosystem, such as the one being developed by the Risk-Informed Systems Analysis (RISA) Pathway under the U.S. Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) Program. The LWRS Program is promoting a wide range of research and development (R&D) activities with the goal to maximize both the safety and economically efficient performance of NPPs through improved scientific understanding, especially given that many plants are considering second license renewal.The RISA Pathway has two main goals: (1) the deployment of methodologies and technologies that enable better representation of safety margins and the factors that contribute to cost and safety; and (2) the development of advanced applications that enable cost-effective plant operation.The plant reload optimization framework development project aims to build a reactor core designing tool that integrates reactor safety and fuel performance analyses and uses artificial intelligence to support optimization of core design solutions.This report summarizes the following activities that were successfully performed in fiscal year (FY)-2022:  Enhancement of a single objective genetic algorithm (GA)-based optimization framework by applying evolution, mutation, survivor, and constraints control methods. Investigation of new experiment data and water droplet models to improve uncertainty analysis in a reflood phenomenon during a loss of coolant accident (LOCA).