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PostprintThis is the accepted version of a paper published in IEEE transactions on neural systems and rehabilitation engineering. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Abstract-Detecting gait events is the key to many gait analysis applications that would benefit from continuous monitoring or long-term analysis. Most gait event detection algorithms using wearable sensors that offer a potential for use in daily living have been developed from data collected in controlled indoor experiments. However, for real-word applications, it is essential that the analysis is carried out in humans' natural environment; that involves different gait speeds, changing walking terrains, varying surface inclinations and regular turns among other factors. Existing domain knowledge in the form of principles or underlying fundamental gait relationships can be utilized to drive and support the data analysis in order to develop robust algorithms that can tackle real-world challenges in gait analysis. This paper presents a novel approach that exhibits how domain knowledge about human gait can be incorporated into time-frequency analysis to detect gait events from longterm accelerometer signals. The accuracy and robustness of the proposed algorithm are validated by experiments done in indoor and outdoor environments with approximately 93,600 gait events in total. The proposed algorithm exhibits consistently high performance scores across all datasets in both, indoor and outdoor environments.

Abstract-Movement asymmetry is one of the motor symptoms associated with Parkinson's disease (PD). Therefore, being able to detect and measure movement symmetry is important for monitoring the patient's condition. The present paper introduces a novel symbol based symmetry index calculated from inertial sensor data. The method is explained, evaluated, and compared to six other symmetry measures. These measures were used to determine the symmetry of both upper and lower limbs during walking of 11 early-to-mid-stage PD patients and 15 control subjects. The patients included in the study showed minimal motor abnormalities according to the unified Parkinson's disease rating scale (UPDRS). The symmetry indices were used to classify subjects into two different groups corresponding to PD or control. The proposed method presented high sensitivity and specificity with an area under the receiver operating characteristic (ROC) curve of 0.872, 9% greater than the second best method. The proposed method also showed an excellent intraclass correlation coefficient (ICC) of 0.949, 55% greater than the second best method. Results suggest that the proposed symmetry index is appropriate for this particular group of patients.

Abstract-Gait analysis can convey important information about one's physical and cognitive condition. Wearable inertial sensor systems can be used to continuously and unobtrusively assess gait during everyday activities in uncontrolled environments. An important step in the development of such systems is the processing and analysis of the sensor data. This paper presents a symbol-based method used to detect the phases of gait and convey important dynamic information from accelerometer signals. The addition of expert knowledge substitutes the need for supervised learning techniques, rendering the system easy to interpret and easy to improve incrementally. The proposed method is compared to an approach based on peak-detection. A new symbol-based symmetry index is created and compared to a traditional temporal symmetry index and a symmetry measure based on cross-correlation. The symbol-based symmetry index exemplifies how the proposed method can extract more information from the acceleration signal than previous approaches.

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