Chronic pain affects the whole person, not just physically, but also psychologically, spiritually and emotionally. Several studies have found a relationship between chronic pain and depression. Nurses play a key role in the treatment of these conditions. Which nursing interventions are referenced in the literature for the relief of pain and depression? were some of the research questions. Our purpose was to identify the nursing interventions referenced in the literature for the relief of chronic pain and depression. An electronic research of articles was performed in the following databases: CINHAL Complete, CINHAL Plus and MEDLINE (via EBSCOhost). Selection criteria: experimental or quasi-experimental studies published between 1st January, 2007 and 31st December, 2014; Participants older than 18 years with chronic pain and depression; Nursing interventions; Results in relieving pain and depression. 17 experimental and quasi-experimental studies were included in the final sample, all with a high level of evidence. Cognitive-behavioural therapy and education were the most frequently referenced interventions, with significant results in the relief of chronic pain and depression. Exercise and relaxation also showed an important contribution to the achievement of positive results in these conditions. Conclusions: There is evidence that the combination of intervention such as cognitive behavioural therapy, education and, eventually, exercise and relaxation, may have a positive contribution in reducing chronic pain and depression. The implementation of these interventions should be encompassed within a complex, multimodal treatment plan and it should be individualized, tailored to the specific characteristics of each individual.