Cooke P., Clifton N. and Oleaga M. (2005) Social capital, firm embeddedness and regional development, Regional Studies 39 , 1065-1077. This paper presents the results of a research project examining the effects of social capital on the performance of small- and medium-sized enterprises (SMEs) in 12 UK regions. It first investigates the association between performance and social capital use at the firm level, then it seeks to move beyond the confines of the individual firm in order to relate these 'firm capabilities' findings to the meso-level to assess regional economic performance in relation to social capital. The research on the conscious use by firms of 'relational embeddedness' in markets shows this to be an important indicator of SME performance, but not conclusively of regional economic performance measured in terms of regional competitiveness.Social capital, Embeddedness, Networks, Small- and medium-sized enterprises (SMEs), Regional development, Valeur de l'interaction sociale, Ancrage, Reseaux, PME, Amenagement du territoire, Sozialkapital, Verankerung, Netzwerke, SMEs, Regionalentwicklung, Capital social, Arraigamiento, Redes, Pymes, Desarrollo regional, JEL classifications: D21, L10, O1, O18,

. Richard Florida argues that regional economic outcomes are tied to the underlying conditions that facilitate creativity and diversity. Thus the Creative Class thesis suggests that the ability to attract creativity and to be open to diverse groups of people of different ethnic, racial and lifestyle groups provides distinct advantages to regions in generating innovations, growing and attracting high‐technology industries, and spurring economic growth. In this paper we investigate the extent to which there might be similar processes concerning the relationship between creativity, human capital, and high‐technology industries at work in the UK as in North America. The approach taken is broadly sympathetic to the Creative Class thesis; critical perspectives and reservations from the literature are introduced as appropriate research is focused around the three principal research questions: Where is the creative class located in the UK? What is the impact of quality of place upon this dispersion? What is the connection between the location of the creative class and inequalities in technical and economic outcomes within the UK? To this end, the creative class and its subgroups are defined and identified. We then construct quality of place indicators relating to tolerance, diversity, creativity and cultural opportunity. To these are added measures of public provision and social cohesion. Data are analysed by means of correlations and regression. In general we find that, although the distribution of the creative class is uneven and complex, our results are consistent with the findings of the North American research with the notable exception of technology‐based employment growth. Finally, priorities for further research are discussed. The need to further investigate causality, variations within the creative class itself, and the potential role of qualitative data in this are highlighted, as is the potential fate of “non‐creative” workers and places.

Sinonasal malignant melanoma is associated with a poor outcome, and survival statistics have not improved over the last 40 years. Treatment should include radical surgery wherever possible. Local recurrence is common; radiotherapy may help control this but does not appear to affect overall survival. The limited evidence available suggests that endoscopic removal of sinonasal malignant melanoma is as effective as other local surgical means, but that craniofacial resection remains the 'gold standard' for tumours that contact or traverse the skull base. Novel biological treatments are emerging and hold promise for the future.

BackgroundFunctional endoscopic sinus surgery (FESS) is now a well-established strategy for the treatment of chronic rhinosinusitis which has not responded to medical treatment. There is a wide variation in the practice of FESS by various surgeons within the UK and in other countries.ObjectivesTo identify anatomic factors that may predispose to persistent or recurrent disease in patients undergoing revision FESS.MethodsRetrospective review of axial and coronal CT scans of patients undergoing revision FESS between January 2005 and November 2008 in a tertiary referral centre in South West of England.ResultsThe CT scans of 63 patients undergoing revision FESS were reviewed. Among the patients studied, 15.9% had significant deviation of the nasal septum. Lateralised middle turbinates were present in 11.1% of the studied sides, and residual uncinate processes were identified in 57.1% of the studied sides. There were residual cells in the frontal recess in 96% of the studied sides. There were persistent other anterior and posterior ethmoidal cells in 92.1% and 96% of the studied sides respectively.ConclusionsAnalysis of CT scans of patients undergoing revision FESS shows persistent structures and non-dissected cells that may be responsible for persistence or recurrence of rhinosinusitis symptoms. Trials comparing the outcome of conservative FESS techniques with more radical sinus dissections are required.

It is increasingly understood that learning and thus innovation often occurs via highly interactive, iterative, network-based processes. Simultaneously, economic development policy is increasingly focused on small and medium-sized enterprises (SMEs) as a means of generating growth, creating a clear research issue in terms of the roles and interactions of government policy, universities, and other sources of knowledge, SMEs, and the creation and dissemination of innovation. This paper analyses the contribution of a range of actors in an SME innovation creation and dissemination framework, reviewing the role of various institutions therein, exploring the contribution of cross-locality networks, and identifying the mechanisms required to operationalise such a framework. Bivariate and multivariate (regression) techniques are employed to investigate both innovation and growth outcomes in relation to these structures; data are derived from the survey responses of over 450 SMEs in the UK. Results are complex and dependent upon the nature of institutions involved, the type of knowledge sought, and the spatial level of the linkages in place but overall highlight the value of cross-locality networks, network governance structures, and certain spillover effects from universities. In general, we find less support for the factors predicting SME growth outcomes than is the case for innovation. Finally, we outline an agenda for further research in the area. Copyright (c) 2010 The Authors. Growth and Change (c) 2010 Wiley Periodicals, Inc..