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Traumatic shock was induced in 130 rats by tumbling them in a Noble-Collip drum for a total of 600 revolutions at 40 rotations/rain. The experimental protocol was designed to evaluate the therapeutic effectiveness of fructose-l,6-diphosphate (FDP) in reducing the mortality rate when given both prior to and following the trauma, or only following the trauma. In the first group (n = 50) in which the treatment was given prior to and after trauma, the animals were randomly assigned to 3 subgroups as follows: 20 rats received 350 mg/kg of FDP prior to and an additional 350 mg/kg after trauma; 20 other rats received in the same manner equal amounts of glucose; and 10 rats received no treatment. In the group treated only after inflicting the injury (n = 80), 35 rats received 350 mg/kg of FDP after trauma; another 35 received glucose; and 10 received no treatment. The rats from the different subgroups were tumbled at the same time.Survival rates in the pretreated subgroups were 85 % for those receiving FDP, 30% for glucose-treated animals (p < 0.005), and 20% for the nontreated ones. In the animals that were treated after trauma, there was also a significant increase in survival rate for the FDP-treated ones (66%), while for those receiving glucose it was 31% (p < 0.01), and 20% for the nontreated ones.The results of the present study and those obtained in other etiological types of shock indicate that FDP has profound antishock therapeutic activity, This action appears to be metabolically mediated by augmenting the endogenous energy production via glycolysis.