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To evaluate the impact of tumor burden and chemotherapy dose scheduling on the response to subconjunctival carboplatin treatment in a murine transgenic retinoblastoma model. Methods: Eighty simian virus 40 T antigen-positive mice were treated at age 5 or 10 weeks. Six control animals received placebo treatment. Twenty-four 5-week-old mice received 6 subconjunctival carboplatin injections at doses of 30 to 300 µg delivered at 72-hour intervals. Fifty 10week-old mice received either 6 or 12 subconjunctival carboplatin injections at doses of 30 to 300 µg delivered at 72-hour intervals. All eyes were obtained at age 16 weeks for histopathologic examination. Eyes were graded as positive if any tumor was present. Results: All simian virus 40 T antigen-positive control eyes contained large tumor foci throughout the retina.