We present a misdiagnosed case of disseminated gonococcal infection (DGI) in a patient with pre-existing systemic lupus erythematosus (SLE), complaining of sudden onset polyarthralgia and tenosynovitis. Neisseria gonorrhoeae is a common sexually transmitted disease. It can present in young adults as cervicitis and urethritis but is often asymptomatic. In rare instances, gonorrhea can advance to DGI with symptoms such as tenosynovitis, dermatitis, and polyarthralgias, seen most commonly in the knees, ankles, elbows, fingers, and toes. Once suspected, DGI is definitively diagnosed with blood cultures or synovial fluid analysis. SLE is associated with an increased risk of disseminated infections, including DGI. Therefore, early diagnosis of DGI is critical for successful treatment and recovery. Providers should therefore be conscientious of the overlap in symptoms between DGI and a lupus flare. The purpose of examining this case is to encourage the inclusion of disseminated N. gonorrhoeae infection as a differential diagnosis in SLE patients presenting with acute arthralgias regardless of genitourinary symptoms.