Introduction: Medication-related Osteonecrosis of the Jaw (MRONJ) is a condition that may affect patients undergoing oral surgery procedures that use antiresorptive drugs. It is essential that the Doctor of Dental Surgery (DDS) is familiar with the pathology and how to diagnose, prevent and approach it. Objectives: To perform a literature review on MRONJ and to guide the DDS on how to manage the affected patients. Methodology: a systematized search was conducted on the PubMed virtual database using the terms: "diphosphonates", "dentist's practice pattern", "dentists", "dentist's role" and "Bisphosphonate-Associated Osteonecrosis of the Jaw". 29 articles in English, published in the last 5 years, were included. Results and discussion: MRONJ is characterized by exposed and necrotic bone that persists for more than 8 weeks and happens in patients taking antiresorptive agents. It is multifactorial and its severity depends on the dosage, route of administration, and treatment duration. Its management must be multidisciplinary to improve the patient's quality of life. The DDS must focus on prevention. Every patient should have their oral health evaluated before starting antiresorptive therapy and be informed of its risks and benefits. Most DDSs do not feel confident to adequately manage these cases, even though information on MRONJ is more widespread among younger DDSs and recent graduates. Conclusion: MRONJ is a harmful condition for the patient and it is the DDS's responsibility to know how to treat and prevent it, by having adequate knowledge of this pathology and making decisions based on the latest scientific evidence.

Objective: The purpose of this paper is to discuss the surgical methods available for the treatment of MRONJ, pointing out their advantages and limitations. Methodology: An integrative review of the literature was performed by searching the PubMed virtual database using the MeSH term "bisphosphonate associated osteonecrosis of the jaw/surgery" and including 26 publications. Results: Surgical intervention is presented as a treatment option in an attempt to reduce disease progression with the recognition that this early intervention may predict beneficial outcomes for the patient. Surgical approaches confer superior treatment outcomes over conservative treatments, with success rates of 80-90% and 10-62%, respectively. To establish treatment, consideration should be given to therapy for removing nonhealing exposed bone, which can be accomplished through curettage, sequestrectomy, and surgical resection. When approaching soft tissue, different flaps can be performed, according to their indications. Conclusion: Surgical treatment has shown maintenance of mucosal coverage, improved quality of life, and quick resumption of antiresorptive therapy for all stages of the disease, with high rates of therapeutic success. However, continued efforts should be encouraged to investigate the best treatment for this pathology.

Introdução: o processo de osseointegração é um processo que permite a interação dos implantes de titânio com o tecido ósseo. No qual essa interface é permeada por um ancoramento proteico de modo em que o biomaterial não fica em contato direto com o periósteo. Objetivo: essa revisão de literatura busca apresentar o processo de adsorção de proteínas em implantes osseointegráveis destacando as principais proteínas que participam desse processo. Metodologia: a pesquisa foi realizada nas plataformas PubMed, SciELO, e Google Acadêmico com artigos publicados entre o período de 2008 a 2022, nos idiomas português e inglês. Resultados: logo após a instalação do implante, ocorre a formação de uma matriz provisória de fibrina (processo de angiogênese) que precede a osseointegração. Em seguida, no espaço de osteocondução, ocorre a interação entre a superfície do implante de titânio com proteínas da membrana plasmática das células. Assim, essa interação proteica subsidiará o ligamento peri-implantar. Contudo, diferentes fatores como propriedades de superfície dos implantes e propriedades das proteínas podem influenciar nesse processo de adsorção. Conclusão: nesse sentido, pode-se presumir que a adsorção de proteínas é um mecanismo imprescindível para o sucesso da osseointegração em implantes de titânio e ligas de titânio.