The confinement due to the COVID-19 pandemic has brought with various social, economic and health problems, significantly impacting the psychological state of people around the world; therefore, the present study aimed to analyze the correlation between the variables of depression, anxiety and stress with family functioning in university men and women, through a non-probabilistic sampling for convenience 256 students of the bachelor’s degree were included, of which 176 were women and 80 men, in a range of 17 to 30 years, to whom the DASS-21 scale and the Instrument Perception of Family Functioning FF-SIL were applied. It was found that there is a significant and negative correlation between the variables studied, which means that the higher the family functioning, lower will be levels of depression, anxiety and stress; in addition, significant differences were found between men and women for the anxiety and stress variables.