BARTHA, JOSE L., PATRICIA MARÍN-SEGURA, NIEVES L. GONZÁ LEZ-GONZÁ LEZ, FERNANDO WAGNER, MANUEL AGUILAR-DIOSDADO, AND BLAS HERVIAS-VIVANCOS. Ultrasound evaluation of visceral fat and metabolic risk factors during early pregnancy. Obesity. 2007;15:2233-2239. Objective: The objective was to study the relationships between ultrasound estimated visceral fat and metabolic risk factors during early pregnancy. Research Methods and Procedures: Thirty consecutive healthy pregnant women at 11 to 14 weeks of gestation were studied. Maximum subcutaneous fat thickness (SFT) and visceral fat thickness (VFT) were successfully measured by ultrasound. Fasting plasma glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and blood pressure were measured. Insulin resistance was calculated by using the homeostasis model assessment (HOMA). Results: VFT significantly correlated with diastolic blood pressure (r ϭ 0.37, p ϭ 0.04), glycemia (r ϭ 0.37, p ϭ 0.04), insulinemia (r ϭ 0.59, p ϭ 0.001) insulin sensitivity (HOMA; r ϭ 0.59, p ϭ 0.001), triglycerides (r ϭ 0.58, p ϭ 0.03), HDL-C (r ϭ Ϫ0.39, p ϭ 0.03), and total cholesterol/ HDL-C ratio (p ϭ 0.002), whereas SFT was significantly correlated with only diastolic blood pressure (p ϭ 0.03). VFT better significantly correlated with the metabolic risk factors than pre-gestational BMI [r ϭ 0.39, p ϭ 0.03 for insulinemia, r ϭ 0.42, p ϭ 0.02 for insulin sensitivity (HOMA), and r ϭ 0.49, p ϭ 0.01 for triglycerides and not significant for the rest]. Discussion: Visceral fat thickness can be easily measured by ultrasound at early pregnancy and correlates better than BMI with metabolic risk factors.

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A combination of low maternal BMI, low cholesterol levels, and high total cholesterol/HDL-C ratio is present in women with sPL and is related to inflammation.