The main aim of this study was to formulate and evaluate the performances off loating In situ gel pantoprazole. Polymers such as sodium alginate and gellangum were used as gelling agents. Sodium citrate and calcium chloride were used for cross linking, whereas calcium carbonate was used as a floating agent. FTIR studies confirmed compatibility between drugs and polymers. The pH of the formulations ranged form of 6.9-7.3, the drug content was found to be between 75.36% to 87.69%, floating lag time was less than 1 min, and floating duration was more than 12h. It was observed that the concentration of polymers increased gelling ability, viscosity, gel strength, and water absorption by the gel. In vitro drug release showed results in the range of 77.80% to 87.12%, at 12 h for all the formulations. The release of the drug was found to decrease with a rise in the concentration of the polymer. All the formulations followed Zero Order kinetics. The drug release mechanism followed the Higuchi diffusion model based on the values of the regression coefficient. Thus an oral In situ floating gelling systems of pantoprazole reduce dosing frequency and enhance the residence time of the drug in the stomach.