Equine ocular setariosis is a serious parasitic condition which causes ocular damage in animals. The present study was aimed to discuss the surgical management and prognosis of ocular setariosis. The affected four horses were presented to Teaching Veterinary Clinical Complex, Mannuthy, with clinical signs like epiphora and corneal cloudiness. The conditions were managed surgically after appropriate anaesthetic administration. All the animals had an uneventful recovery and attained complete corneal clarity.