Papillomavirus (PV) DNA is frequently uncovered in samples of human skin squamous cell carcinomas (SCC). However, the role of these viruses in the development of such cancers in canine species remains controversial. While approximately 100 human PVs are known, only one single canine oral PV (COPV) has been identified and studied extensively. Therefore, we applied a narrow-range polymerase chain reaction (PCR) suitable for the detection of classical canine and feline PVs, as well as a broad-range PCR, which has been used for the detection of various novel PVs in humans, in order to analyse 42 paraffin-embedded samples, representing three different forms of canine SCCs. Ten samples of skin tissues with various non-neoplastic conditions served as controls. While none of the negative controls reacted positively, PV DNA was discovered in 21% of the tested SCC samples. Interestingly, the classical COPV was amplified from only one sample, while the other positive cases were associated with a variety of thus far unknown PVs. This study suggests that a fraction of canine SCC is infected with PVs and that a genetic variety of canine PVs exists. Therefore, these results will facilitate the future study of the role of PVs in the development of canine skin cancers.

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Recent research has shown that available tools for Modern Code Review (MCR) are still far from meeting the current expectations of developers. The objective of this paper is to investigate the approaches and tools that, from a developer’s point of view, are still needed to facilitate MCR activities. To that end, we first empirically elicited a taxonomy of recurrent review change types that characterize MCR. The taxonomy was designed by performing three steps: (i) we generated an initial version of the taxonomy by qualitatively and quantitatively analyzing 211 review changes/commits and 648 review comments of ten open-source projects; then (ii) we integrated into this initial taxonomy, topics, and MCR change types of an existing taxonomy available from the literature; finally, (iii) we surveyed 52 developers to integrate eventually missing change types in the taxonomy. Results of our study highlight that the availability of new emerging development technologies (e.g., Cloud-based technologies) and practices (e.g., Continuous delivery) has pushed developers to perform additional activities during MCR and that additional types of feedback are expected by reviewers. Our participants provided recommendations, specified techniques to employ, and highlighted the data to analyze for building recommender systems able to automate the code review activities composing our taxonomy. We surveyed 14 additional participants (12 developers and 2 researchers), not involved in the previous survey, to qualitatively assess the relevance and completeness of the identified MCR change types as well as assess how critical and feasible to implement are some of the identified techniques to support MCR activities. Thus, with a study involving 21 additional developers, we qualitatively assess the feasibility and usefulness of leveraging natural language feedback (automation considered critical/feasible to implement) in supporting developers during MCR activities. In summary, this study sheds some more light on the approaches and tools that are still needed to facilitate MCR activities, confirming the feasibility and usefulness of using summarization techniques during MCR activities. We believe that the results of our work represent an essential step for meeting the expectations of developers and supporting the vision of full or partial automation in MCR.

Skin physiology in cats has received little attention. The aim of this study was to evaluate the long-term influence of sex, time and the level of dietary fat and energy on the dynamics and qualities of the hair coat. Twenty-four European short-haired laboratory cats were followed over a 1-year period. They were divided into eight groups of three, according to: sex (12 males and 12 females), sexual status (intact or neutered) and diets [(high energy 4300 kcal/kg as fed, 21% fat) vs. (moderate energy 3500 kcal/kg as fed, 10% fat)]. Both diets were fed for 6 months to all cats following a cross-over design. The following parameters were evaluated throughout the study: thickness of hair coat and hair lengths (neck, rump, lateral, flank), hair regrowth (after periodic clippings of 25 cm 2 areas), and telogen/anagen ratio. The thickness of the hair coat initially varied from 1.2-1.7 cm on the neck, 1-1.4 cm on the rump, 1.8-2.5 cm on the flank, and hair shaft lengths were 1.7-2.5, 3.7-3.9 and 2.5-3.2 cm, respectively. Comparison of values revealed few statistical differences: increase of the thickness of hair coat in neutered cats (male and female) during the study, and increase of the length of lateral hairs in all groups during the study. Over all periods and in all groups, the curve of growth was similar (rapid then slower). Some transient variations were attributed to temporary changes in ambient conditions. In conclusion, neither sex, nutrition or season (in housed cats) influenced the general quality of hair coat, in particular hair regrowth. Funding: Royal Canin. Veterinary Dermatology 2004, 15 (Suppl. 1), 41-69 Ó 2004 ESVD and ACVD 41 Poster Abstracts Poster Abstracts