Antimicrobial resistance (AMR) is a growing global health problem. Staphylococcus aureus is a commonest bacterium associated with community acquired and nosocomial infections. Methicillin resistant strains are increasingly being reported worldwide. In this study, we determined the prevalence and antimicrobial susceptibility pattern of Methicillin resistant Staphylococcus aureus (MRSA), isolated from various clinical specimens from a tertiary care hospital. The study comprised of 545 strains of Staphylococcus aureus isolated from various clinical specimens using standard microbiological procedures. From these isolates, methicillin resistant strains were screened, and their antimicrobial susceptibility pattern was detected according to CLSI 2020 guidelines. Out of 545 strains a total of 358 Strains were found to be methicillin resistant. In this study all MRSA strains were Vancomycin sensitive and majority of the MRSA strains were linezolid susceptible. However, Vancomycin intermediate and Linezolid resistant strains has been reported in some studies, but not found in our study.

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Background: Pyogenic infections can be caused by various microorganisms and may co-exist as poly microbial infections which require antibiotic therapy. The inappropriate use of antibiotics has led to major problems of MDRO's contributing to morbidity and mortality. Even though the bacteriological prole of pus samples in many studies remain the same, antimicrobial susceptibility pattern of these isolates has shown a lot of variation. This study was conducted to assess bacteriological prole of pus samples and their antimicrobial susceptibility pattern Materials and Methods:Aretrospective study was carried out from April to June 2021. 540 pus culture aerobic bacterial isolates were included. The samples were cultured on Blood and MacConkey agar. After aerobic incubation at 37oC for 18-24 hrs, organisms were identied by conventional bacteriology methods as per laboratory protocol and antimicrobial susceptibility was tested by Kirby Bauer disc diffusion method as per CLSI 2020 guideline. Results: Out of 540 pus isolates , 452(83.7%)were gram negative bacili and 88(16.3%) were gram positive cocci Pseudomonas spp. 173(31.9%), was most common gram negative isolate while S.. aureus 66(12.19%) was most common Gram positive isolate. Most of gram negative isolates were susceptible to Imipenem and Polymyxin and gram positive isolates to vancomycin and linezolid . Conclusion: To combat resistance irrational use of antibiotics should be avoided. Also regular surveillance helps in implementing better therapeutic strategies to reduce morbidity and mortality