Background: Laboratory biomarkers/radiological ndings are less expensive, faster and easier to obtain. As such, they have been the preferred modality to monitor and predict outcomes and prognosis of COVID 19. Present study was aimed to study laboratory bio markers, CT severity in patients, had mortality due to COVID19 at tertiary care hospital. Material and Methods: Present study was single-center, retrospective, case record based study, conducted among case records of patients of age ≥15 yrs, with COVID RT-PCR positive (oropharyngeal or nasopharyngeal swab) or HRCT-CHESTsuggestive of COVID 19. Results:Among 100 patients, died due to COVID 19 related complications. majority of patients were elderly, from > 64 years age group (55 %), male gender (68 %) had pre-existing morbidity such as Diabetes (53 %), Cardiovascular disease/ Hypertension (25 %), Chronic lung disease (11%). Complications such as Acute Respiratory Distress Syndrome (81 %), Septic shock (65 %), Disseminated Intravascular Coagulation (47 %), Acute Kidney Injury (17 %), Myocardial infarction (17 %) & Liver failure (11 %) were noted among non-survivor patients. Mortality was noted more in 06-10 days (37 %), followed by 11-15 days (26 %), 15-25 days (24 %), ≤ 5 days (9 %) & least was among admitted >25 days (4 %). In patients not survived in COVID 19 infection, raised levels of white blood cell count, neutrophils count, PT, aPTT, serum potassium, direct bilirubin, indirect bilirubin, total bilirubin, AST, ALT, LDH, CRP, D-dimer & procalcitonin while reduced levels of platelets, PaO2 (mmHg), SpO2 (%) were noted. Conclusion: Raised levels of white blood cell count, neutrophils count, PT, aPTT, serum potassium, direct bilirubin, indirect bilirubin, total bilirubin, AST, ALT, LDH, CRP, D-dimer & procalcitonin. while reduced levels of platelets, PaO2 (mmHg), SpO2 were major laboratory bio markers/CTseverity in patients who had mortality due to COVID19
Objectives: Several unique characteristics have been found in severe COVID19, such as lymphopenia, old age, high CRP level, elevated D dimer levels and underlying comorbid diseases. Serum albumin, being a negative acute phase reactant has been found to be associated with inflammatory response and poor outcomes in infectious diseases. The aim of the study was to analyse whether the serum albumin levels on admission might reflect the severity of systemic inflammation in COVID 19 infection and thus serve as an early predictive factor for COVID 19 outcomes. Materials and Method: This retrospective observational study included 185 COVID-19 positive patients. Laboratory data was recorded from blood samples collected at admission and analyzed by standard methods in the laboratory. Hypoalbuminemia was defined as serum albumin levels <3.5g/dl. p < 0.05 was considered statistically significant. Results: In the 185 COVID 19 patients studied, average age was 51.29 (±15.68) years. The study population had a male predominance (68.11%). 85 (45.95%) individuals were found to have hypoalbuminemia on admission. 18 (9.73%) deaths were reported amongst the study population and a significant association was found between low serum albumin levels on admission and mortality.(p < 0.001).
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