Radiotherapy plays an important role in the multimodal treatment of childhood cancer. Our objective was to provide an analysis of pediatric oncology patients treated with radiotherapy in a national referral institution in Serbia. A retrospective chart review of children treated with radiotherapy between January 2007 and July 2018 was conducted. Of the 806 patients who were identified, 767 formed the basis of this study. CNS tumors (31.2%) were the most common tumors followed by leukemias (17.3%) and bone tumors (14.3%). The most common indication for radiotherapy was in adjuvant setting (69.1%). Anesthesia or sedation was performed on 115 patients. The 5-year and 10-year overall survival rates were 65.7% and 62.1%, respectively. A significant difference in survival in relation to tumor type was seen. The best survival rates were obtained in patients with retinoblastoma, followed by lymphomas and nephroblastoma, while patients with bone sarcomas had the worst survival. The intent of radiotherapy treatment was also a parameter associated with survival. Patients treated with palliative and definitive intent lived shorter than patients treated with prophylactic and adjuvant intent. Our study showed that good treatment outcomes can be achieved in specialized centers with an experienced team of professionals who are dedicated to pediatric oncology.

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Echocardiography is essential for the diagnosis of infective endocarditis (IE), treatment choice and follow-up. Prognosis in IE is multifactorial and includes both structural changes of the heart induced by IE and extra-cardiac IE complications. Aims Aims of the study were to analyse: 1) relation between embolic complications of IE and structural changes of the heart detected by echocardiography in IE patients; 2) association between embolic complications of IE and IE causative microorganism. Methods 335 patients with definitive IE from the single tertiary center were enrolled in the study between 2009–2018. Echocardiographic changes are defined in accordance with 2015 ESC guideline. Associations between embolic complication and structural heart changes, as well as between IE causative microorganism and embolic complications were tested by Chi square test. Results Observed embolic complication were: ischemic stroke (in 12.5% of patients), haemorrhagic stroke (2.1%), neuroinfection (9.6%), brain abscess (1.8%), discitis (3%), pulmonary embolism (1.5%), spleen abscess (7.8%) and peripheral arterial embolization (1.5%). There were several significance associations: vegetations larger than 15 mm were associated with ischemic stroke (p=0.041) and peripheral arterial embolization (p=0.05); perivalvular abscess was associated with brain abscess (p=0.037) and peripheral arterial embolization (p=0.019). Staphylococcus aureus isolated from blood cultures was associated with discitis (p<0.001), brain abscess (p<0.001) and neuroinfection (p<0.001). Bacterias from HACEK group were associated with peripheral arterial embolisation (p<0.001) and non-HACEK bacterias were associated with ichemic stroke (p=0.016). Patients with more than one isolated bacteria from blood culture had more often spleen abscess (p=0.003) and ichemic stroke (p=0.049). Conclusion Results point that large vegetations, but also perivalvular abscesses are coupled with higher rate of embolic complications in patients with IE. Staphylococcus aureus, HACEK group and non-HACEK bacteria are, more than other causative IE microorganisms, associated with embolism. These results might be clinically important for treatment chose and prognosis of the patients with IE.

Upoređivanje prikupljenih podataka projekta EuReCa sprovedene tokom 2015. i 2016. godine kao i njihova uzajamna analiza, u istraživačkom centru Subotica. Metod: Prospektivna studija, observacionog trijala Evropskog Resuscitacionog saveta koji je pod brojem NCT02236819 registrovan u bazi trijala i odobren od zdravstvenih autoriteta u SAD. Analizirani su prikupljeni podaci u Službi za hitnu medicinsku pomoć Subotica. Podaci su prikupljani tokom cele 2015. i 2016.godine i od strane glavnog istraživača unošeni u jedinstvenu bazu podataka putem onlajn unosa i aplikacije postavljene na adresi www.eureca.rs.