Biodegradable implants are required in order to provide successful treatment of injuries. Temporary magnesium‐based implants with particular properties are needed in cases when it is desirable not only to maintain vital activity, but also to initiate the self‐healing process of damaged bones or tissues as well. Unfortunately, the use of magnesium alloys is limited due to the fast biodegradability of the applied material. The aim of this research is to improve the corrosion resistance of magnesium alloys by sonochemical treatment in silk solution followed by additional layer‐by‐layer deposition of natural silk on the magnesium surface. The sonication process is carried out at a frequency of 20 kHz during 5–10 min, while the duration of the silk layer deposition is 15 min. The corrosion behavior of magnesium substrates modified by natural silk layer‐by‐layer assembly is studied. Magnesium substrates sonochemically treated in silk solution demonstrate three times better corrosion resistance compared to control samples sonochemically treated in water. Additional deposition of a silk layer enhances obtained corrosion resistance by 18 times, resulting in a 54‐fold increase overall.

Front Cover: In article number 1900412 by Ekaterina V. Skorb, Elena F. Krivoshapkina, and co‐workers, magnesium implants sonochemically treated in silk solution demonstrate significant improvement of corrosion resistance compared to control samples sonochemically treated in water. The deposition of a silk layer enhances the obtained corrosion resistance by 18 times, resulting in a 54‐fold increase overall. Thus, hybrid effects of sonochemical oxidative protection combined with silk assembly is promising for a new generation of bioinspired implants.

The use of dynamic, adaptive materials with feedback control is a tendency of the past decade. Life sciences and medicine require materials with the controlled and responsive assembly of various components on the scales from molecular to macroscopic and even robotics. The main idea of this review is the use of synthetic systems as regulatory networks that facilitate the integration of chemical and biological materials. The synthetic systems, which are inspired by biochemical regulatory networks, help synthetic material to adapt to environmentand to interact with living matter cooperatively. The first step in realizing this concept is designing simple model systems. The simplicity means that the system should contain a minimal number of components but should be robust and sustainable to perform the required functions through logic operations and feedback loops. Here we suggest specific examples of robust systems for the selected functionality: compartmentalized signaling cascades, computation with light-induced chemical gradients andadvanced biomimetic mixed organic-inorganic materials, and self-regulation in chemical-biological systems. The main challenges for the given examples are discussed, and future prospects of logic operation with chemical systems are provided.